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Vacuolar Protein Sorting 36 Homolog (S. Cerevisiae) (VPS36) (Internal Region) antibody
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|3 references available|
|Quantity||100 µl (Variants)|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||Vacuolar protein-sorting-associated protein 36 (VPS36)|
|Immunogen||A synthetic peptide from the internal part of mouse Vacuolar protein-sorting-associated protein 36 (VPS36) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat.|
|Description||FUNCTION: Component of the ESCRT-II complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery oftransmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. SUBCELLULAR LOCATION: Cytoplasm. Late endosome. Nucleus. NoteL Colocalizes with ubiquitinated proteins on late endosomes. Also known as: VPS36.|
|Specificity||Appears to be specific for VPS36.|
|Synonyms||EAP45, C13orf9, CGI-145, DKFZp781E0871, RGD1309754, fj33d07, zgc:55965, wu:fj33d07, MGC157100, MUG13.23, MUG13_23, VPS36, CG10711, DmelCG10711, l(3)L5212, vps36, Eap45, 1700010A24Rik, 2210415M20Rik, 2810408E15Rik, MGC84611|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Kamura, Burian, Khalili et al.: "Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 16528-33, 2001 (PubMed).
Gibbs, Weinstock, Metzker et al.: "Genome sequence of the Brown Norway rat yields insights into mammalian evolution." in: Nature, Vol. 428, Issue 6982, pp. 493-521, 2004 (PubMed).
Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).
|Reactivities||Mouse (Murine) (3), Human (2)|
|Applications||Western Blotting (WB) (5), Immunohistochemistry (IHC) (2), Immunohistochemistry (Fixed) (IHC (fx)) (1), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (1)|
|Epitopes||Internal Region (3), N-Term (2)|