Vesicle-Associated Membrane Protein 8 (Endobrevin) (VAMP8) (Internal Region) antibody

Details for Product No. ABIN351341
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Antigen
Synonyms EDB, VAMP-8, Edb, AU041171, endobrevin, zgc:56588, wu:fa18d07, vamp8
Epitope
Internal Region
(7), (5), (2), (2), (2), (1), (1), (1)
Reactivity
Zebrafish
(27), (17), (16), (12), (12), (12), (2)
Host
Rabbit
(29), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(22), (10), (7), (5), (4), (3), (2), (2)
Pubmed 5 references available
Catalog no. ABIN351341
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from the internal region of human VAMP8 conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 97% identity with mouse and rat sequence.
Isotype IgG
Specificity Specific for TRPM3.
Purification whole serum
Alternative Name Vesicle associated membrane protein 8 (VAMP8, Endobrevin)
Background Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes.
Subcellular location: Membrane, Single-pass type IV membrane protein
Tissue specificity: Platelets Also known as: VAMP8, VAMP-8, Endobrevin.
UniProt A2BGS8
Research Area Signaling, Metabolism
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Wong, Zhang, Xu et al.: "Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome." in: Molecular biology of the cell, Vol. 9, Issue 6, pp. 1549-63, 1998 (PubMed).

Antonin, Holroyd, Tikkanen et al.: "The R-SNARE endobrevin/VAMP-8 mediates homotypic fusion of early endosomes and late endosomes." in: Molecular biology of the cell, Vol. 11, Issue 10, pp. 3289-98, 2000 (PubMed).

Polgár, Chung, Reed: "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion." in: Blood, Vol. 100, Issue 3, pp. 1081-3, 2002 (PubMed).

Low, Li, Miura et al.: "Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells." in: Developmental cell, Vol. 4, Issue 5, pp. 753-9, 2003 (PubMed).

Hillier, Graves, Fulton et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4...." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005 (PubMed).

Hosts (29), (2)
Reactivities (27), (17), (16), (12), (12), (12), (2)
Applications (22), (10), (7), (5), (4), (3), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (5), (2), (2), (2), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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