Vacuolar Protein Sorting 26 Homolog A (S. Pombe) (VPS26A) (internal) antibody

Antigen: Vacuolar Protein Sorting 26 Homolog A (S. Pombe) (VPS26A)

Synonyms: VPS26A, MNC6.7, MNC6_7, VACUOLAR PROTEIN SORTING 26A, DKFZp459G2011, HB58, PEP8A, VPS26, Hbeta58, FLJ12930, Vps26, AA407240, MGC94168, MGC139062

Epitope: internal

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351347

Additional Information

Alternative name: Vesicle protein sorting 26A (VPS26, VPS26A) (internal region)

Swiss-Prot: O75436

Immunogen: A synthetic peptide from the internal region of human Vesicle protein sorting 26A (VPS26, VPS26A) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.

Format: Lyophilized

Description: FUNCTION: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane; Peripheral membrane protein. Also known as: Vacuolar protein sorting-associated protein 26A, VPS26, VPS26, VP26A.

Specificity: Appears to be specific for VPS26A.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Images

WB on rat brain lysate using Rabbit antibody to internal region of Vesicle protein sorting 26A (VPS26, VPS26A): whole serum (ABIN351347) at 1 : 1000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the detected band.

Publications

Publications: Lee, Radice, Perkins et al.: "Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion." in: Development (Cambridge, England), Vol. 115, Issue 1, pp. 277-88, 1992 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).