Vesicle-Associated Membrane Protein 1 (Synaptobrevin 1) (VAMP1) (AA 2-35) antibody

Details for Product No. ABIN351355
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Antigen
Synonyms VAMP1, syb1, vamp-1, An12g07570, Syb-1, Syb1, VAMP-1, lew, SYB1
Epitope
AA 2-35
(8), (5), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine)
(53), (32), (25), (15), (14), (13), (12), (12), (3), (1), (1)
Host
Rabbit
(35), (26), (6), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(54), (19), (16), (15), (10), (9), (6), (3), (3), (3), (1)
Pubmed 5 references available
Quantity 500 μg
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Catalog No. ABIN351355
454.67 $
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Immunogen A synthetic peptide from aa region 2-35 of mouse VAMP-1 conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for VAMP1.
Alternative Name VAMP-1
Background Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Subunit: Interacts with VAPA and VAPB.
Subcellular location: Isoform 1: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.
Subcellular location: Isoform 2: Cytoplasmic vesicle membrane, Single-pass type IV membrane protein. Note: Isoforms 2 and 3 are found in perinuclear as well as peripheral punctate structures in osteoblasts.
Subcellular location: Isoform 3: Mitochondrion outer membrane, Single-pass type IV membrane protein. Note=Isoforms 2 and 3 are found in perinuclear as well as peripheral punctate structures in osteoblasts.
Tissue specificity: Expressed in brain and spleen (at protein level). Isoform 1 expressed at very high level in brain. Even higher level found in spinal cord. Isoform 3 expressed in kidney, spleen and liver. Isoforms 2 and 3 expressed in osteoblasts of trabecular bone. Also expressed in heart. Also known as: VAMP-1, Vamp1, Synaptobrevin-1, Syb1.
Application Notes A working concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Elferink, Trimble, Scheller: "Two vesicle-associated membrane protein genes are differentially expressed in the rat central nervous system." in: The Journal of biological chemistry, Vol. 264, Issue 19, pp. 11061-4, 1989 (PubMed).

Mandic, Trimble, Lowe: "Tissue-specific alternative RNA splicing of rat vesicle-associated membrane protein-1 (VAMP-1)." in: Gene, Vol. 199, Issue 1-2, pp. 173-9, 1997 (PubMed).

Pruele, Horton, Caterina et al.: "Identification of the molecular mechanisms contributing to polarized trafficking in osteoblasts." in: Experimental cell research, Vol. 282, Issue 1, pp. 24-34, 2002 (PubMed).

Vosseller, Hansen, Chalkley et al.: "Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol." in: Proteomics, Vol. 5, Issue 2, pp. 388-98, 2005 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome. ..." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

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