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Vesicle-Associated Membrane Protein, Associated Protein B and C (VAPB) antibody

Details for Product No. ABIN351368
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Antigen
Synonyms AI225786, AI840687, AI848259, D2Abb2e, R75548, VAP33b, Vamp33b
Reactivity
Mouse (Murine)
(1)
Host
Rabbit
(1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(1), (1)
Pubmed 7 references available
Quantity 500 µg
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Catalog No. ABIN351368
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from human VAMP B conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in many species including human, rat, mouse, zebra fish, bovine, xenopus and chicken.
Specificity Specific for MOR2-1.
Purification IgG
Alternative Name Vesicle-associated membrane protein-associated protein B (VAMP-B)
Background Function: May play a role in vesicle trafficking.
Subunit: Homodimer, and heterodimer with VAPA. Interacts with VAMP1 and VAMP2.
Subcellular location: Cell membrane, Single-pass type IV membrane protein. Intracytoplasmic membrane, Single-pass type IV membrane protein. Note: Present in the plasma membrane and in intracellular vesicles.
Tissue specificity: Ubiquitous. Isoform 1 predominates. DISEASE: Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8 (ALS8). ALS8 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms. DISEASE: Defects in VAPB are a cause of proximal adult autosomal dominant spinal muscular atrophy, also called late-onset spinal muscular atrophy Finkel type. Spinal muscular atrophies are neurodegenerative disorders characterized by degeneration of lower motor neurons, leading to progressive paralysis muscular atrophy. This form is a late- adult-onset form of the disease (after age 20 years). The patients show a benign course, most of them remaining ambulatory 10 to 40 years after clinical onset. Also known as: VAMP-associated protein B, VAMP-B, VAP-B, Vesicle-associated membrane protein-associated protein B/C, VAMP-associated protein B/C, VAMP-B/VAMP-C, VAP-B/VAP-C, VAPB.
UniProt Q9EPN9
Research Area Neurology
Application Notes A concentration of 10-50 µg/mL of is recommended.
The optimal concentration should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
General Nishimura, Hayashi, Inada et al.: "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins." in: Biochemical and biophysical research communications, Vol. 254, Issue 1, pp. 21-6, 1999 (PubMed).

Hu, Han, Song et al.: "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 17, pp. 9543-8, 2000 (PubMed).

Deloukas, Matthews, Ashurst et al.: "The DNA sequence and comparative analysis of human chromosome 20." in: Nature, Vol. 414, Issue 6866, pp. 865-71, 2002 (PubMed).

Gevaert, Goethals, Martens et al.: "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." in: Nature biotechnology, Vol. 21, Issue 5, pp. 566-9, 2003 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Nousiainen, Silljé, Sauer et al.: "Phosphoproteome analysis of the human mitotic spindle." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 14, pp. 5391-6, 2006 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Hosts (1)
Reactivities (1)
Applications (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN351368
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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