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Details for Product No. ABIN351371

SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae) (Gene/pseudogene) (SEC22B) antibody

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Antigen
Synonyms ERS-24, SEC22L1, C81333, Sec22l1, AA517334, AI480645, 4930564D15Rik, ers-24, sec22b, sec22l1
Reactivity
»Alternatives Human, Rat (Rattus), Mouse (Murine), Hamster, Orang-Utan, Chicken
Host
»Alternatives Sheep
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 10 references available
Catalog no. ABIN351371
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide as a part of human, rat, mouse, hamster, orangutan, chicken Vesicle-trafficking protein SEC22b (SEC22B, SEC22L1, ERS24) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for SEC22B.
Purity whole serum
Alternative Name Vesicle-trafficking protein SEC22b (SEC22B, SEC22L1, ERS24)
Background The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins. There is evidence for use of multiple polyadenylation sites for the transcript.
Function: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
Subunit: Component of two distinct SNARE complexes consisting of STX5,GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex.
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane, Single-pass type IV membrane protein. Golgi apparatus membrane, Single-pass type IV membrane protein. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Also known as: SEC22 vesicle-trafficking protein homolog B, SEC22 vesicle-trafficking protein-like 1, ERS24, ERS-24, Vesicle-trafficking protein SEC22b, SEC22L1, SEC22B.
UniProt O75396
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 5000 is recommended. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Hay, Chao, Kuo et al.: "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells." in: Cell, Vol. 89, Issue 1, pp. 149-58, 1997 (PubMed).

Mao, Fu, Wu et al.: "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 14, pp. 8175-80, 1998 (PubMed).

Xu, Joglekar, Williams et al.: "Subunit structure of a mammalian ER/Golgi SNARE complex." in: The Journal of biological chemistry, Vol. 275, Issue 50, pp. 39631-9, 2001 (PubMed).

Gonzalez, Weis, Scheller: "A novel snare N-terminal domain revealed by the crystal structure of Sec22b." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 24203-11, 2001 (PubMed).

Volchuk, Ravazzola, Perrelet et al.: "Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack." in: Molecular biology of the cell, Vol. 15, Issue 4, pp. 1506-18, 2004 (PubMed).

Nakajima, Hirose, Taniguchi et al.: "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion." in: The EMBO journal, Vol. 23, Issue 16, pp. 3216-26, 2004 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Chi, Valencia, Hu et al.: "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes." in: Journal of proteome research, Vol. 5, Issue 11, pp. 3135-44, 2006 (PubMed).

Villén, Beausoleil, Gerber et al.: "Large-scale phosphorylation analysis of mouse liver." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 5, pp. 1488-93, 2007 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Alternatives for antigen "SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae) (Gene/pseudogene) (SEC22B)", type "Antibodies"
Hosts (11), (6), (3)
Reactivities (19), (9), (7), (3), (3), (3)
Applications (19), (8), (6), (5), (2), (2), (2), (1), (1)
Epitopes (3), (2), (1), (1), (1), (1)
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