Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 7 (SLC17A7) (AA 500-560) antibody

Details for Product No. ABIN351378, Supplier: Log in to see
Antigen
Epitope
AA 500-560
37
28
6
5
2
2
2
1
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
67
63
52
2
2
1
1
1
1
1
Host
Rabbit
45
18
8
4
3
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
69
57
17
13
12
8
5
4
4
2
2
2
1
1
1
Options
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Immunogen A synthetic peptide from aa region 500-560 of rat VGluT1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and human.
Specificity Specific for VGLUT1 (both isoforms 1 and 2).
Purification Whole serum
Alternative Name VGluT1
Background Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane, Multi-pass membrane protein. Cell junction, synapse, synaptosome. Also known as: Vesicular glutamate transporter 1, VGlU1, Solute carrier family 17 member 7, Brain-specific Na(+)-dependent inorganic phosphate cotransporter, Bnpi.
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 7 (SLC17A7) (AA 500-560) antibody (ABIN351378) WB on rat brain lysate using Rabbit antibody to a cytoplasmic loop of VGluT1 (VGLU1, ...
Background publications Gras, Amilhon, Lepicard, Poirel, Vinatier, Herbin, Dumas, Tzavara, Wade, Nomikos, Hanoun, Saurini, Kemel, Gasnier, Giros, El Mestikawy: "The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone." in: Nature neuroscience, Vol. 11, Issue 3, pp. 292-300, 2008 (PubMed).

Mackenzie, Illing, Morris, Varoqui, Erickson: "Analysis of a vesicular glutamate transporter (VGLUT2) supports a cell-leakage mode in addition to vesicular packaging." in: Neurochemical research, Vol. 33, Issue 2, pp. 238-47, 2008 (PubMed).

Nogami, Ogasawara, Mimura, Mogi, Shutoh, Hisano: "Developmentally-regulated expression of tissue-specific splice variant of rat vesicular glutamate transporter 1 in retina and pineal gland." in: Journal of neurochemistry, Vol. 99, Issue 1, pp. 142-53, 2006 (PubMed).

Takamori, Holt, Stenius, Lemke, Grønborg, Riedel, Urlaub, Schenck, Brügger, Ringler, Müller, Rammner, Gräter, Hub, De Groot, Mieskes, Moriyama, Klingauf, Grubmüller, Heuser, Wieland, Jahn: "Molecular anatomy of a trafficking organelle." in: Cell, Vol. 127, Issue 4, pp. 831-46, 2006 (PubMed).

Herzog, Bellenchi, Gras, Bernard, Ravassard, Bedet, Gasnier, Giros, El Mestikawy: "The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 22, pp. RC181, 2001 (PubMed).

Fremeau, Troyer, Pahner, Nygaard, Tran, Reimer, Bellocchio, Fortin, Storm-Mathisen, Edwards: "The expression of vesicular glutamate transporters defines two classes of excitatory synapse." in: Neuron, Vol. 31, Issue 2, pp. 247-60, 2001 (PubMed).

Takamori, Rhee, Rosenmund, Jahn: "Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2)." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 22, pp. RC182, 2001 (PubMed).

Takamori, Rhee, Rosenmund, Jahn: "Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons." in: Nature, Vol. 407, Issue 6801, pp. 189-94, 2000 (PubMed).

Ni, Rosteck, Nadi, Paul: "Cloning and expression of a cDNA encoding a brain-specific Na(+)-dependent inorganic phosphate cotransporter." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 12, pp. 5607-11, 1994 (PubMed).

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