VGluT1 (VGLU1, Slc17a7, Bnpi, Vesicular Glutamate Transporter 1) (Cytoplasmic Loop) antibody

Details for Product No. ABIN351380
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Antigen
Epitope
Cytoplasmic Loop
(1), (1)
Reactivity
Rat (Rattus), Mouse (Murine)
(2), (1), (1)
Host
Rabbit
(2)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB), Flow Cytometry (FACS)
(2), (2), (2)
Pubmed 9 references available
Catalog no. ABIN351380
Quantity 100 µL
Price
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Immunogen A synthetic peptide from a cytoplasmic loop of rat VGluT1 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for P2RX2.
Purification whole serum
Background Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane, Multi-pass membrane protein. Cell junction, synapse, synaptosome. Also known as: Vesicular glutamate transporter 1, VGlU1, Solute carrier family 17 member 7, Brain-specific Na(+)-dependent inorganic phosphate cotransporter, Bnpi.
UniProt Q8K3P1
Research Area Cancer, Channels, Transporters
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Ni, Rosteck, Nadi et al.: "Cloning and expression of a cDNA encoding a brain-specific Na(+)-dependent inorganic phosphate cotransporter." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 12, pp. 5607-11, 1994 (PubMed).

Takamori, Rhee, Rosenmund et al.: "Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons." in: Nature, Vol. 407, Issue 6801, pp. 189-94, 2000 (PubMed).

Fremeau, Troyer, Pahner et al.: "The expression of vesicular glutamate transporters defines two classes of excitatory synapse." in: Neuron, Vol. 31, Issue 2, pp. 247-60, 2001 (PubMed).

Herzog, Bellenchi, Gras et al.: "The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 22, pp. RC181, 2001 (PubMed).

Takamori, Rhee, Rosenmund et al.: "Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2)." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 22, pp. RC182, 2001 (PubMed).

Nogami, Ogasawara, Mimura et al.: "Developmentally-regulated expression of tissue-specific splice variant of rat vesicular glutamate transporter 1 in retina and pineal gland." in: Journal of neurochemistry, Vol. 99, Issue 1, pp. 142-53, 2006 (PubMed).

Takamori, Holt, Stenius et al.: "Molecular anatomy of a trafficking organelle." in: Cell, Vol. 127, Issue 4, pp. 831-46, 2006 (PubMed).

Mackenzie, Illing, Morris et al.: "Analysis of a vesicular glutamate transporter (VGLUT2) supports a cell-leakage mode in addition to vesicular packaging." in: Neurochemical research, Vol. 33, Issue 2, pp. 238-47, 2008 (PubMed).

Gras, Amilhon, Lepicard et al.: "The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone." in: Nature neuroscience, Vol. 11, Issue 3, pp. 292-300, 2008 (PubMed).

Hosts (2)
Reactivities (2), (1), (1)
Applications (2), (2), (2)
Epitopes (1), (1)
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