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VGluT1 (VGLU1, Slc17a7, Bnpi, Vesicular glutamate transporter 1) (Cytoplasmic Loop) antibody
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|9 references available|
|Quantity||100 µl (Variants)|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide from a cytoplasmic loop of rat VGluT1 (VGLU1, Slc17a7, Bnpi, Vesicular glutamate transporter 1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 92% identity with mouse's and 90% with human's.|
|Description||FUNCTION: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome. Also known as: Vesicular glutamate transporter 1, VGlU1, Solute carrier family 17 member 7, Brain-specific Na(+)-dependent inorganic phosphate cotransporter, Bnpi.|
|Specificity||Appears to be specific for VGLUT1 (both isoforms 1 and 2).|
|Application Notes||IHC, WB, Flow Cyt. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Ni, Rosteck, Nadi et al.: "Cloning and expression of a cDNA encoding a brain-specific Na(+)-dependent inorganic phosphate cotransporter." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 12, pp. 5607-11, 1994 (PubMed).
Takamori, Rhee, Rosenmund et al.: "Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons." in: Nature, Vol. 407, Issue 6801, pp. 189-94, 2000 (PubMed).
Fremeau, Troyer, Pahner et al.: "The expression of vesicular glutamate transporters defines two classes of excitatory synapse." in: Neuron, Vol. 31, Issue 2, pp. 247-60, 2001 (PubMed).
Herzog, Bellenchi, Gras et al.: "The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 22, pp. RC181, 2001 (PubMed).
Takamori, Rhee, Rosenmund et al.: "Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2)." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 22, pp. RC182, 2001 (PubMed).
Nogami, Ogasawara, Mimura et al.: "Developmentally-regulated expression of tissue-specific splice variant of rat vesicular glutamate transporter 1 in retina and pineal gland." in: Journal of neurochemistry, Vol. 99, Issue 1, pp. 142-53, 2006 (PubMed).
Takamori, Holt, Stenius et al.: "Molecular anatomy of a trafficking organelle." in: Cell, Vol. 127, Issue 4, pp. 831-46, 2006 (PubMed).
Mackenzie, Illing, Morris et al.: "Analysis of a vesicular glutamate transporter (VGLUT2) supports a cell-leakage mode in addition to vesicular packaging." in: Neurochemical research, Vol. 33, Issue 2, pp. 238-47, 2008 (PubMed).
Gras, Amilhon, Lepicard et al.: "The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone." in: Nature neuroscience, Vol. 11, Issue 3, pp. 292-300, 2008 (PubMed).
|Hosts||Rabbit (1), Sheep (1)|
|Applications||Immunohistochemistry (IHC) (2), Western Blotting (WB) (2)|
|Epitopes||Cytoplasmic Loop (2)|