Vomeronasal 1 Receptor, A2 (V1ra2) antibody

Antigen: Vomeronasal 1 Receptor, A2 (V1ra2)

Synonyms: V1r2, V1RA9, V1ra2, mV1R2, V1ra11, V1RA2, V1ra5, V1ra13, Vom1r94

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse (Murine)

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351393

Additional Information

Alternative name: vomeronasal 1 receptor, A2 (VN1A2, V1A11)

Swiss-Prot: Q8VIC7

Immunogen: A synthetic peptide as a part of mouse vomeronasal 1 receptor, A2 (VN1A2, V1A11) conjugated to immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Putative pheromone receptor implicated in the regulation of social and reproductive behavior. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Expressed in a subset of sensory neurons located in the apical layer of thevomeronasal organ. MISCELLANEOUS: Mice lacking all but one V1RA and V1RB gene (12% of the V1R repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Useful Links <||a href="http://bioportal.weizmann.ac.il/HORDE/links.html"> The Humanolfactory Data Exploratorium: HORDE <||/a> <||a href="http://senselab.med.yale.edu/senselab/ordb/">olfactory Receptor Data Base: ORDB <||/a> <||a href="http://www.enzim.hu/hmmtop1.1/server/submit.html">transmembrane Analysis: TM analysis<||/a> Also known as:vomeronasal type-1 receptor A2, pheromone receptor 2,vomeronasal type-1 receptor A9, mV1R2, V1ra2, Pr2, V1ra9, V1ra11,vomeronasal type-1 receptor A11, V1RA9, V1r2.

Specificity: Appears to be specific for VN1A2.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Saito, Mimmack, Keverne et al.: "Isolation of mouse vomeronasal receptor genes and their co-localization with specific G-protein messenger RNAs." in: Brain research. Molecular brain research, Vol. 60, Issue 2, pp. 215-27, 1998 (PubMed).

Rodriguez, Del Punta, Rothman et al.: "Multiple new and isolated families within the mouse superfamily of V1r vomeronasal receptors." in: Nature neuroscience, Vol. 5, Issue 2, pp. 134-40, 2002 (PubMed).

Del Punta, Leinders-Zufall, Rodriguez et al.: "Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes." in: Nature, Vol. 419, Issue 6902, pp. 70-4, 2002 (PubMed).