Vomeronasal 1 Receptor A1 (V1ra1) antibody

Antigen: Vomeronasal 1 Receptor A1 (V1ra1)

Synonyms: V1R, V1r1, VN12, V1ra1, mV1R1, V1RA1, V1RA3, V1ra6, Vn1, Vom1r105

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse (Murine)

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351395

Additional Information

Alternative name: vomeronasal type-1 receptor A1 (VN1A1, mV1R1, V1ra1, Pr1, V1ra8, V1R, V1r1, VN12)

Swiss-Prot: Q8VIC6

Immunogen: A synthetic peptide as a part of mouse vomeronasal type-1 receptor A1 (VN1A1, mV1R1, V1ra1, Pr1, V1ra8, V1R, V1r1, VN12) conjugated to immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in a subset of sensory neurons located in the apical layer of thevomeronasal organ. MISCELLANEOUS: Mice lacking all but one V1RA and V1RB gene (12% of the V1R repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Useful Links <||a href="http://bioportal.weizmann.ac.il/HORDE/links.html" > The Humanolfactory Data Exploratorium: HORDE <||/a> <||a href="http://senselab.med.yale.edu/senselab/ordb/" >olfactory Receptor Data Base: ORDB <||/a> <||a href="http://www.enzim.hu/hmmtop1.1/server/submit.html" >transmembrane Analysis: TM analysis<||/a> Also known as:vomeronasal type-1 receptor A8, pheromone receptor 1, VN1A1, mV1R1, V1ra1, Pr1, V1ra8, V1R, V1r1, VN12.

Specificity: Appears to be specific for VN1A1.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Saito, Mimmack, Keverne et al.: "Isolation of mouse vomeronasal receptor genes and their co-localization with specific G-protein messenger RNAs." in: Brain research. Molecular brain research, Vol. 60, Issue 2, pp. 215-27, 1998 (PubMed).

Del Punta, Rothman, Rodriguez et al.: "Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse." in: Genome research, Vol. 10, Issue 12, pp. 1958-67, 2000 (PubMed).

Lane, Cutforth, Axel et al.: "Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 1, pp. 291-6, 2002 (PubMed).

Del Punta, Leinders-Zufall, Rodriguez et al.: "Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes." in: Nature, Vol. 419, Issue 6902, pp. 70-4, 2002 (PubMed).