Vomeronasal Type-1 Receptor A7/A8 (VN1A7/VN1A8) antibody

Antigen: Vomeronasal Type-1 Receptor A7/A8 (VN1A7/VN1A8)

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse (Murine)

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351401

Additional Information

Alternative name: vomeronasal type-1 receptor A7A8 (VN1A7, VN1A8)

Swiss-Prot: Q9EP79

Immunogen: A synthetic peptide as a part of mouse vomeronasal type-1 receptor A7 (VN1A7, V1ra7, VN3) and vomeronasal type-1 receptor A8 (VN1A8, V1ra8) conjugated to immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Putative pheromone receptor implicated in the regulation of social and reproductive behavior. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in a subset of sensory neurons located in the apical layer of thevomeronasal organ. MISCELLANEOUS: Mice lacking all but one V1RA and V1RB gene (12% of the V1R repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Also known as: VN1A7, V1ra7, VN3,vomeronasal receptor 3, pheromone receptor VN3; VN1A8, V1ra8.

Specificity: Appears to be specific for VN1A7 and VN1A8.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Rodriguez, Feinstein, Mombaerts: "Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system." in: Cell, Vol. 97, Issue 2, pp. 199-208, 1999 (PubMed).

Del Punta, Rothman, Rodriguez et al.: "Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse." in: Genome research, Vol. 10, Issue 12, pp. 1958-67, 2000 (PubMed).

Del Punta, Leinders-Zufall, Rodriguez et al.: "Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes." in: Nature, Vol. 419, Issue 6902, pp. 70-4, 2002 (PubMed).