Vomeronasal 1 Receptor, B1 (V1rb1) antibody

Antigen: Vomeronasal 1 Receptor, B1 (V1rb1)

Synonyms: VN2, V1RA5, V1rb1, MGC130072

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse (Murine)

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351403

Additional Information

Alternative name: vomeronasal type-1 receptor B1 (VN1B1, V1rb1, V1ra5, VN2, V1RA5)

Swiss-Prot: Q9EP51

Immunogen: A synthetic peptide as a part of mouse vomeronasal type-1 receptor B1 (VN1B1, V1rb1, V1ra5, VN2, V1RA5) conjugated to immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Putative pheromone receptor implicated in the regulation of social and reproductive behavior. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in a subset of sensory neurons located in the apical layer of thevomeronasal organ. MISCELLANEOUS: Mice lacking all but one V1RA and V1RB gene (12% of the V1R repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. <||a href="http://www.enzim.hu/hmmtop1.1/server/submit.html" /> Also known as: VN1B1, V1rb1, V1ra5, VN2, V1RA5,vomeronasal type-1 receptor A5,vomeronasal receptor 2, pheromone receptor VN2, MGC130072.

Specificity: Appears to be specific for VN1B1.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Del Punta, Rothman, Rodriguez et al.: "Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse." in: Genome research, Vol. 10, Issue 12, pp. 1958-67, 2000 (PubMed).

Lane, Cutforth, Axel et al.: "Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 1, pp. 291-6, 2002 (PubMed).

Del Punta, Leinders-Zufall, Rodriguez et al.: "Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes." in: Nature, Vol. 419, Issue 6902, pp. 70-4, 2002 (PubMed).