Vomeronasal Type-1 Receptor B2B4 (V1rb2) antibody

Antigen: Vomeronasal Type-1 Receptor B2B4 (V1rb2)

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse (Murine)

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351405

Additional Information

Alternative name: vomeronasal type-1 receptor B2B4 (VN1B2, V1rb2, VRi2)

Swiss-Prot: Q9WUF1

Immunogen: A synthetic peptide as a part of mouse vomeronasal type-1 receptor B2 (VN1B2, V1rb2, VRi2) and vomeronasal type-1 receptor B4 (VN1B4, vomeronasal type-1 receptor A10, vomeronasal type-1 receptor B11, V1ra10, V1rb11, V1rb4) conjugated to immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Putative pheromone receptor implicated in the regulation of social and reproductive behavior. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in a subset of sensory neurons located in the apical layer of thevomeronasal organ. MISCELLANEOUS: Mice lacking V1RB2 show a disrupted pattern of axonal projections to the accessoryolfactory bulb. MISCELLANEOUS: Mice lacking all but one V1RA and V1RB gene (12% of the V1R repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Useful Links <||a href="http://bioportal.weizmann.ac.il/HORDE/links.html" > The Humanolfactory Data Exploratorium: HORDE <||/a> <||a href="http://senselab.med.yale.edu/senselab/ordb/" >olfactory Receptor Data Base: ORDB <||/a> <||a href="http://www.enzim.hu/hmmtop1.1/server/submit.html" >transmembrane Analysis: TM analysis<||/a> Also known as:vomeronasal receptor VRi2, V1rb2, VN1B2; (see the Immunogen) and VN1B4,vomeronasal type-1 receptor B4,vomeronasal type-1 receptor A10,vomeronasal type-1 receptor B11, V1ra10, V1rb11, V1rb4.

Specificity: Appears to be specific for VN1B2 and also VN1B4 (see the Immunogen).

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Rodriguez, Feinstein, Mombaerts: "Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system." in: Cell, Vol. 97, Issue 2, pp. 199-208, 1999 (PubMed).

Del Punta, Rothman, Rodriguez et al.: "Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse." in: Genome research, Vol. 10, Issue 12, pp. 1958-67, 2000 (PubMed).

Del Punta, Leinders-Zufall, Rodriguez et al.: "Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes." in: Nature, Vol. 419, Issue 6902, pp. 70-4, 2002 (PubMed).