Vomeronasal 1 Receptor, B3 (V1rb3) antibody

Antigen: Vomeronasal 1 Receptor, B3 (V1rb3)

Synonyms: VN5, V1rb3

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse (Murine)

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351406

Additional Information

Alternative name: vomeronasal type-1 receptor B3 (VN1B3, V1rb3, VN5, pheromone receptor VN5)

Swiss-Prot: Q9EP93

Immunogen: A synthetic peptide as a part of mouse vomeronasal type-1 receptor B3 (VN1B3, V1rb3, VN5, pheromone receptor VN5) conjugated to immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Putative pheromone receptor implicated in the regulation of social and reproductive behavior. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. MISCELLANEOUS: Mice lacking all but one V1RA and V1RB gene (12% of the V1R repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. NOTE: This gene was found (PubMed:11752409) to lack a conserved putative promoter and, therefore, may not be transcribed. Nevertheless, this product (OSR00234W) is a high titre antibody. Tested by ELISA, it specifically recognizes the immunising peptide. It would be very interesting to see whether or not the protein is indeed expressed. While we are investigating this, contact us for more details. Useful Links <||a href="http://bioportal.weizmann.ac.il/HORDE/links.html" > The Humanolfactory Data Exploratorium: HORDE <||/a> <||a href="http://senselab.med.yale.edu/senselab/ordb/" >olfactory Receptor Data Base: ORDB <||/a> <||a href="http://www.enzim.hu/hmmtop1.1/server/submit.html" >transmembrane Analysis: TM analysis<||/a> Also known as:vomeronasal receptor 5, pheromone receptor VN5, V1rb3.

Specificity: Appears to be specific for VN1B3.

Application Details

Application Notes: IHC, WB (potential). This is a high titre antibody. Tested by ELISA, it specifically recognizes the immunising peptide. It would be very interesting to see whether or not the protein is indeed expressed. While we are investigating this, contact us for more details.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Del Punta, Rothman, Rodriguez et al.: "Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse." in: Genome research, Vol. 10, Issue 12, pp. 1958-67, 2000 (PubMed).

Lane, Cutforth, Axel et al.: "Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 1, pp. 291-6, 2002 (PubMed).

Del Punta, Leinders-Zufall, Rodriguez et al.: "Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes." in: Nature, Vol. 419, Issue 6902, pp. 70-4, 2002 (PubMed).