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VTA1 antibody (Vps20-Associated 1 Homolog (S. Cerevisiae)) (Internal Region)

Details for Product anti-VTA1 Antibody No. ABIN351413, Supplier: Log in to see
  • 1110001D18Rik
  • 1110059P08Rik
  • AU040813
  • C6orf55
  • C85340
  • DRG-1
  • DRG1
  • Lip5
  • LIP5
  • My012
  • RGD1305031
  • SBP1
Internal Region
Immunohistochemistry (IHC), Western Blotting (WB)
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Immunogen A synthetic peptide from the internal region of human VTA1 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for VTA1.
Purification Whole serum
Alternative Name VTA1 (VTA1 Antibody Abstract)
Background Function: Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR. Involved in HIV-1 budding.
Subcellular location: Cytoplasm. Endosome membrane, Peripheral membrane protein Also known as: Vacuolar protein sorting-associated protein VTA1 homolog, Dopamine-responsive protein DRG-1, SKD1 binding protein 1, SBP1, LYST-interacting protein 5, LIP5.
Research Area Signaling
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Ward, Vaughn, Shiflett, White, Pollock, Hill, Schnegelberger, Sundquist, Kaplan: "The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells." in: The Journal of biological chemistry, Vol. 280, Issue 11, pp. 10548-55, 2005 (PubMed).

Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

Wiemann, Weil, Wellenreuther, Gassenhuber, Glassl, Ansorge, Böcher, Blöcker, Bauersachs, Blum, Lauber, Düsterhöft, Beyer, Köhrer, Strack, Mewes, Ottenwälder, Obermaier, Tampe, Heubner, Wambutt, Korn et al.: "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. ..." in: Genome research, Vol. 11, Issue 3, pp. 422-35, 2001 (PubMed).

Zhang, Ye, Wu, Ren, Zhao, Zhao, Fu, Shen, Fan, Lu, Zhong, Xu, Han, Zhang, Tao, Huang, Zhou, Hu, Gu, Chen, Chen: "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." in: Genome research, Vol. 10, Issue 10, pp. 1546-60, 2000 (PubMed).