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Wolfram Syndrome 1 (Wolframin) (WFS1) antibody

Antigen

Wolfram Syndrome 1 (Wolframin) (WFS1)
Synonyms WFS, WFRS, FLJ51211, WOLFRAMIN, DmelCG4917, CG4917, GB15257, WFS1
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
4 references available
Catalog no. ABIN351414
Quantity 100 µl  (Variants)
Price 454.67 $   Plus shipping costs $45.00
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Additional Information
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Alternative name WFS1 (Wolframin)
UniProt Q9JLT5
Immunogen A synthetic peptide from the aa 100-200 of mouse WFS1 (Wolframin) conjugated to an immunogenic carrier protein was used as the immunogen. The peptide is homologous in rat.
Format Lyophilized
Description FUNCTION: Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Also known as: Wolframin.
Specificity Appears to be specific for WFS1.

Application Details
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Application Notes IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Purity whole serum
Storage Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Inoue, Tanizawa, Wasson et al.: "A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)." in: Nature genetics, Vol. 20, Issue 2, pp. 143-8, 1998 (PubMed).

Strom, Hoertnagel, Hofmann et al.: "Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein." in: Human molecular genetics, Vol. 7, Issue 13, pp. 2021-8, 1999 (PubMed).

Takeda, Inoue, Tanizawa et al.: "WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain." in: Human molecular genetics, Vol. 10, Issue 5, pp. 477-84, 2001 (PubMed).

Munton, Tweedie-Cullen, Livingstone-Zatchej et al.: "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 2, pp. 283-93, 2007 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Wolfram Syndrome 1 (Wolframin) (WFS1)", type "Antibodies"
Hosts Rabbit (27)
Reactivities Human (25), Mouse (Murine) (24), Rat (Rattus) (23), Cow (Bovine) (19), Dog (Canine) (19), Horse (Equine) (18), Cat (Feline) (1), Chicken (1)
Applications Immunofluorescence (IF) (18), Western Blotting (WB) (12), ELISA (8), Immunohistochemistry (IHC) (6), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes AA 100-200 (1), N-Term (1)