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Details for Product No. ABIN351415

Wolfram Syndrome 1 (WFS1) (AA 100-200) antibody

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Antigen
Synonyms CG4917, Dmel\\CG4917, GB15257, WFS1
Epitope
»Alternatives AA 100-200
Reactivity
»Alternatives Human, Rat (Rattus), Mouse (Murine)
Host
»Alternatives Sheep
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN351415
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the aa 100-200 of mouse WFS1 (Wolframin) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat.
Isotype IgG
Specificity Specific for VGLUT1 (both isoforms 1 and 2).
Purity IgG
Alternative Name WFS1 (Wolframin)
Background Function: Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store.
Subcellular location: Endoplasmic reticulum membrane, Multi-pass membrane protein. Also known as: Wolframin.
UniProt Q9P2U7
Application Notes A concentration of 10-50 µg/mL is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Inoue, Tanizawa, Wasson et al.: "A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)." in: Nature genetics, Vol. 20, Issue 2, pp. 143-8, 1998 (PubMed).

Strom, Hoertnagel, Hofmann et al.: "Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein." in: Human molecular genetics, Vol. 7, Issue 13, pp. 2021-8, 1999 (PubMed).

Takeda, Inoue, Tanizawa et al.: "WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain." in: Human molecular genetics, Vol. 10, Issue 5, pp. 477-84, 2001 (PubMed).

Munton, Tweedie-Cullen, Livingstone-Zatchej et al.: "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 2, pp. 283-93, 2007 (PubMed).

Alternatives for antigen "Wolfram Syndrome 1 (WFS1)", type "Antibodies"
Hosts (24), (1)
Reactivities (23), (23), (22), (12), (12)
Applications (15), (10), (6), (6), (6), (5), (5), (4), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (3), (2)
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