Wolfram Syndrome 1 (WFS1) (AA 100-200) antibody

Details for Product No. ABIN351415
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Antigen
Synonyms CG4917, Dmel\\CG4917, GB15257, WFS1, WFRS, WFS, WFSL, AI481085, wolframin
Epitope
AA 100-200
(3), (2), (2), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine)
(24), (21), (20), (12), (12)
Host
Rabbit
(26), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(17), (10), (8), (5), (4), (3), (3), (3)
Pubmed 4 references available
Quantity 500 μg
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Catalog No. ABIN351415
454.67 $
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Immunogen A synthetic peptide from the aa 100-200 of mouse WFS1 (Wolframin) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat.
Isotype IgG
Specificity Specific for WFS1.
Alternative Name WFS1
Background Function: Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store.
Subcellular location: Endoplasmic reticulum membrane, Multi-pass membrane protein. Also known as: Wolframin.
Research Area Neurology
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 200 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Inoue, Tanizawa, Wasson et al.: "A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)." in: Nature genetics, Vol. 20, Issue 2, pp. 143-8, 1998 (PubMed).

Strom, Hoertnagel, Hofmann et al.: "Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein." in: Human molecular genetics, Vol. 7, Issue 13, pp. 2021-8, 1999 (PubMed).

Takeda, Inoue, Tanizawa et al.: "WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain." in: Human molecular genetics, Vol. 10, Issue 5, pp. 477-84, 2001 (PubMed).

Munton, Tweedie-Cullen, Livingstone-Zatchej et al.: "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 2, pp. 283-93, 2007 (PubMed).

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