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Zic Family Member 1/2/3 (Zic1/2/3) (C-Term) antibody

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Human, Rat (Rattus), Mouse (Murine)
(2), (2), (2)
(1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(2), (2)
Pubmed 5 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from c-terminal region of human ZIC3 (Zinc finger protein ZIC 3) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in many species including rat and mouse.
Specificity Specific for ZIC1,2 , 3.
Purification Whole serum
Alternative Name ZIC1-3
Background Function: Probably functions as a transcription factor in the earliest stages of the left-right (LR) body axis formation. Defects in ZIC3 are the cause of X-linked visceral heterotaxy (HTX1). HTX1 is a disease characterized by congenital heart disease and alterations of visceral situs, including asplenia or polysplenia, symmetric liver, intestinal malrotation, and abnormal lung lobation. Also known as: HTX, HTX1, Zic family member 3 (odd-paired Drosophila homolog heterotaxy 1), Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3), ZNF203.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Chhin, Hatayama, Bozon et al.: "Elucidation of penetrance variability of a ZIC3 mutation in a family with complex heart defects and functional analysis of ZIC3 mutations in the first zinc finger domain." in: Human mutation, Vol. 28, Issue 6, pp. 563-70, 2007 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome. ..." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Ware, Peng, Zhu et al.: "Identification and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects." in: American journal of human genetics, Vol. 74, Issue 1, pp. 93-105, 2003 (PubMed).

Gebbia, Ferrero, Pilia et al.: "X-linked situs abnormalities result from mutations in ZIC3." in: Nature genetics, Vol. 17, Issue 3, pp. 305-8, 1997 (PubMed).

Catalog No. ABIN351416
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