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Details for Product No. ABIN351416

Zinc Finger Protein ZIC 1, 2, 3 (ZIC1, 2, 3) antibody

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Antigen
Reactivity
»Alternatives Human, Rat (Rattus), Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN351416
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from c-terminal region of human ZIC3 (Zinc finger protein ZIC 3) conjugated to an immunogenic carrier protein was used as the immunogen. The peptide is homologous in many species including rat and mouse.
Specificity Appears to be specific for ZIC3.
Purity whole serum
Alternative Name ZIC1, 2, 3 (Zinc finger protein ZIC 1, 2, 3)
Background Function: Probably functions as a transcription factor in the earliest stages of the left-right (LR) body axis formation. Defects in ZIC3 are the cause of X-linked visceral heterotaxy (HTX1). HTX1 is a disease characterized by congenital heart disease and alterations of visceral situs, including asplenia or polysplenia, symmetric liver, intestinal malrotation, and abnormal lung lobation. Also known as: HTX, HTX1, Zic family member 3 (odd-paired Drosophila homolog heterotaxy 1), Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3), ZNF203.
UniProt O60481
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Gebbia, Ferrero, Pilia et al.: "X-linked situs abnormalities result from mutations in ZIC3." in: Nature genetics, Vol. 17, Issue 3, pp. 305-8, 1997 (PubMed).

Ware, Peng, Zhu et al.: "Identification and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects." in: American journal of human genetics, Vol. 74, Issue 1, pp. 93-105, 2003 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Chhin, Hatayama, Bozon et al.: "Elucidation of penetrance variability of a ZIC3 mutation in a family with complex heart defects and functional analysis of ZIC3 mutations in the first zinc finger domain." in: Human mutation, Vol. 28, Issue 6, pp. 563-70, 2007 (PubMed).

Alternatives for antigen "Zinc Finger Protein ZIC 1, 2, 3 (ZIC1, 2, 3)", type "Antibodies"
Hosts (1)
Reactivities (1), (1), (1)
Applications (1), (1)
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