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Zic Family Member 1/2/3 (Zic1/2/3) (C-Term) antibody

Details for Product No. ABIN351417
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Antigen
Epitope
C-Term
(2)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(2), (2), (2)
Host
Rabbit
(1), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(2), (2)
Pubmed 5 references available
Quantity 500 µg
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Catalog No. ABIN351417
454.67 $
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Immunogen A synthetic peptide from c-terminal region of human ZIC3 (Zinc finger protein ZIC 3) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in many species including rat and mouse.
Isotype IgG
Specificity Specific for ZIC1, 2, 3.
Alternative Name ZIC1-3
Background Function: Probably functions as a transcription factor in the earliest stages of the left-right (LR) body axis formation. Defects in ZIC3 are the cause of X-linked visceral heterotaxy (HTX1). HTX1 is a disease characterized by congenital heart disease and alterations of visceral situs, including asplenia or polysplenia, symmetric liver, intestinal malrotation, and abnormal lung lobation. Also known as: HTX, HTX1, Zic family member 3 (odd-paired Drosophila homolog heterotaxy 1), Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3), ZNF203.
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Gebbia, Ferrero, Pilia et al.: "X-linked situs abnormalities result from mutations in ZIC3." in: Nature genetics, Vol. 17, Issue 3, pp. 305-8, 1997 (PubMed).

Ware, Peng, Zhu et al.: "Identification and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects." in: American journal of human genetics, Vol. 74, Issue 1, pp. 93-105, 2003 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Chhin, Hatayama, Bozon et al.: "Elucidation of penetrance variability of a ZIC3 mutation in a family with complex heart defects and functional analysis of ZIC3 mutations in the first zinc finger domain." in: Human mutation, Vol. 28, Issue 6, pp. 563-70, 2007 (PubMed).

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