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Prostaglandin D2 Receptor 2 (PTGDR2) antibody

Details for Product No. ABIN351421, Supplier: Log in to see
Antigen
  • CRTH2
  • GPR44
  • Crth2
  • Grp45
  • Ptgdr2
  • CD294
  • DL1R
  • DP2
  • Gpr44
Reactivity
Human
100
35
32
2
Host
Mouse
79
20
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
51
40
31
30
16
11
7
4
4
2
2
2
1
Supplier
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Immunogen Partial peptide of Human GPR44
Clone 8F2
Isotype IgG1, kappa chain
Purification Protein G Affinity Purified
Alternative Name G protein-coupled receptor 44 (GPR44, CD294) (PTGDR2 Antibody Abstract)
Background CRTH2, also known as GPR44, DP2, CD294, is a member of G protein-coupled receptor and activated by prostaglandin D2 (PGD2) and its PGD2 metabolites. CRTH2 is predominantly expressed on Th2-type T cells, eosinophils and basophils and mediates their chemotaxis to PGD2. CRTH2 mediates the respiratory burst and degranulation of eosinophils, induces the production of proinflammatory cytokines in Th2 cells, and enhances the release of histamine from basophils. PGD2- CRTH2 system also may play important roles in the development of chronic allergic skin inflammation.
Gene ID 11251
Research Area Inflammation
Application Notes Recommended Dilutions: Western Blotting 20ug/ml, ELISA 1ug/ml
Restrictions For Research Use only
Concentration 0.25 mg/ml
Buffer PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Preservative ProClin
Storage -20 °C
Background publications Satoh, Moroi, Aritake et al.: "Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 4, pp. 2621-9, 2006 (PubMed).

Iwasaki, Nagata, Takano et al.: "Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis." in: The Journal of investigative dermatology, Vol. 119, Issue 3, pp. 609-16, 2002 (PubMed).