Prostaglandin D2 Receptor 2 (PTGDR2) antibody

Antigen: Prostaglandin D2 Receptor 2 (PTGDR2)

Synonyms: DP2, CD294, CRTH2, Crth2, Grp45, MGC130436, GPR44

Clonality: Monoclonal (8F2)

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Catalog no.: ABIN351421

Additional Information

Alternative name: G protein-coupled receptor 44 (GPR44, CD294)

Gene ID: 11251

Immunogen: Partial peptide of Human GPR44

Format: Affinity-purified

Isotype: IgG1, kappa chain

Clone: 8F2

Description: CRTH2, also known as GPR44, DP2, CD294, is a member of G protein-coupled receptor and activated by prostaglandin D2 (PGD2) and its PGD2 metabolites. CRTH2 is predominantly expressed on Th2-type T cells, eosinophils and basophils and mediates their chemotaxis to PGD2. CRTH2 mediates the respiratory burst and degranulation of eosinophils, induces the production of proinflammatory cytokines in Th2 cells, and enhances the release of histamine from basophils. PGD2- CRTH2 system also may play important roles in the development of chronic allergic skin inflammation.

Application Details

Application Notes: Recommended Dilutions: Western Blotting 20ug/ml, ELISA 1ug/ml

Concentration: 0.25 mg/ml

Purification: Protein G Affinity Purified

Buffer: PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]

Storage: Store below -20°C

Research Area: Inflammation

Restrictions: For Research Use only

Images

Lysates from human cancer cell lines

Publications

Iwasaki, Nagata, Takano et al.: "Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis." in: The Journal of investigative dermatology, Vol. 119, Issue 3, pp. 609-16, 2002 (PubMed).

Satoh, Moroi, Aritake et al.: "Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 4, pp. 2621-9, 2006 (PubMed).