Prostaglandin D2 Receptor 2 (PTGDR2) antibody

Details for Product No. ABIN351421
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Antigen
Synonyms CRTH2, GPR44, Crth2, Grp45, Ptgdr2, CD294, DL1R, DP2, Gpr44
Reactivity
Human
(70), (39), (34)
Host
Mouse
(71), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(43), (32), (31), (14), (10), (8), (5), (1)
Pubmed 2 references available
Quantity 50 µg
Shipping to United States (Change)
Availability Will be delivered in 9 to 11 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN351421
948.34 $
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Immunogen Partial peptide of Human GPR44
Clone 8F2
Isotype IgG1, kappa chain
Purification Protein G Affinity Purified
Alternative Name G protein-coupled receptor 44 (GPR44, CD294)
Background CRTH2, also known as GPR44, DP2, CD294, is a member of G protein-coupled receptor and activated by prostaglandin D2 (PGD2) and its PGD2 metabolites. CRTH2 is predominantly expressed on Th2-type T cells, eosinophils and basophils and mediates their chemotaxis to PGD2. CRTH2 mediates the respiratory burst and degranulation of eosinophils, induces the production of proinflammatory cytokines in Th2 cells, and enhances the release of histamine from basophils. PGD2- CRTH2 system also may play important roles in the development of chronic allergic skin inflammation.
Gene ID 11251
Research Area Inflammation
Application Notes Recommended Dilutions: Western Blotting 20ug/ml, ELISA 1ug/ml
Restrictions For Research Use only
Concentration 0.25 mg/ml
Buffer PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Preservative ProClin
Storage -20 °C
General Iwasaki, Nagata, Takano et al.: "Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis." in: The Journal of investigative dermatology, Vol. 119, Issue 3, pp. 609-16, 2002 (PubMed).

Satoh, Moroi, Aritake et al.: "Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 4, pp. 2621-9, 2006 (PubMed).

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