Myc Tag (AA 423-435) antibody

Details for Product No. ABIN351513, Supplier: Log in to see
Antigen
Epitope
AA 423-435
56
9
6
4
3
2
2
2
2
2
1
1
Reactivity
Tag
217
41
14
12
6
5
3
1
1
Host
Mouse
163
64
21
17
3
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
28
24
15
9
5
4
4
4
4
4
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
227
121
82
54
52
39
22
19
18
7
6
5
5
5
5
4
3
3
3
2
1
1
1
1
1
1
1
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Supplier Product No.
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Brand IHC-plus™
Immunogen Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of human c-myc. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%), Orangutan, Monkey, Marmoset, Tamarin (92%), Rat, Sheep, Hamster, Panda, Dog, Horse (85%).

Type of Immunogen: Synthetic peptide
Clone 9E10
Isotype IgG1
Specificity The antibody 9E10 may be used to detect the c-Myc tag. The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells
Predicted Reactivity Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%) Orangutan, Monkey, Marmoset, Tamarin (92%) Rat, Sheep, Hamster, Panda, Dog, Horse (85%).
Purification Protein G purified
Target Type Tag
UniProt P01106
Application Notes Approved: Flo (1 - 5 μg/mL), IHC-P (10 μg/mL), IP (1 - 5 μg/mL), WB (0.5 - 2 μg/mL)

Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody,
Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer PBS, 15 mM sodium azide, approx, pH 7.4.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C,-20 °C
Storage Comment +4°C or -20°C, Avoid repeated freezing and thawing.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Myc Tag (AA 423-435) antibody (ABIN351513) Human Liver (formalin-fixed, paraffin-embedded) stained with c-Myc antibody ABIN35151...
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