MDS1 and EVI1 Complex Locus (MECOM) (N-Term) antibody

Details for Product No. ABIN356376, Supplier: Log in to see
Antigen
  • evi1
  • im:7140716
  • prdm3
  • EVI1
  • AML1-EVI-1
  • MDS1
  • MDS1-EVI1
  • PRDM3
  • D630039M04Rik
  • Evi-1
  • Evi1
  • Jbo
  • Mds
  • Mds1
  • Mds1-Evi1
  • Prdm3
  • Znfpr1b1
  • AML1
  • AMLCR1
  • CBFA2
  • EVI-1
  • PEBP2aB
  • MDS1 and EVI1 complex locus
  • runt-related transcription factor 1
  • mecom
  • MECOM
  • LOC100343228
  • Mecom
  • RUNX1
Epitope
N-Term
28
17
17
15
9
5
5
4
4
3
3
2
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
105
33
9
4
4
3
3
2
1
1
1
Host
Mouse
72
30
15
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
6
6
6
6
6
6
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
104
65
11
5
3
2
1
1
1
1
Options
Supplier
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Immunogen This antibody was raised using purified recombinant GST fusion protein encoding theN-terminal part of human PRDM3.
Clone 47AT612-84-88
Isotype IgG1
Specificity This antibody is specific to PRDM3.
Characteristics Synonyms: Myelodysplasia syndrome 1, Myelodysplasia syndrome-associated protein 1
Purification Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MDS1 (MECOM Antibody Abstract)
Background Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. MDS1, first identified as part of a fusion transcript resulting from the t(3,21)(q26,q22), encodes a small protein of unknown function. EVI1 encodes a zinc finger protein inappropriately overexpressed by chromosomal rearrangements. EVI1 and MDS1 are unusual in that they can either encode separate proteins, or they can be expressed as a fusion protein MDS1/EVI1. EVI1 and MDS1/EVI1 have opposite functions as transcription factors.Synonyms: Myelodysplasia syndrome 1, Myelodysplasia syndrome-associated protein 1
Gene ID 2122
UniProt Q13465
Application Notes ELISA: 1/1,000. Western blotting: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-MDS1 and EVI1 Complex Locus (MECOM) (N-Term) antibody (ABIN356376) anti-MDS1 and EVI1 Complex Locus (MECOM) (N-Term) antibody
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