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PRMT7 antibody (Protein Arginine Methyltransferase 7) (N-Term)

Details for Product anti-PRMT7 Antibody No. ABIN356532, Supplier: Log in to see
Antigen
  • 4933402B05Rik
  • ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 7
  • ATPRMT7
  • BC006705
  • DL4310W
  • FCAALL.195
  • protein arginine methyltransferase 7
  • RGD1304869
  • zgc:66172
Epitope
N-Term
11
8
7
6
4
4
3
3
1
1
1
1
Reactivity
Human
60
18
7
2
1
1
1
1
1
Host
Rabbit
47
12
4
Clonality
Polyclonal
Conjugate
This PRMT7 antibody is un-conjugated
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
59
19
11
10
5
2
2
1
1
Supplier
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Supplier Product No.
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide in the N-terminal region of human PRMT7.
Isotype Ig
Specificity This antibody is specific to PRMT7 (N-term).
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name PRMT7 (PRMT7 Antibody Abstract)
Background Arginine methylation is an irreversible post translational modification which has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These protein include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Outside of these domains, epitopes were identified and antibodies against all 7 PRMT members have been developed.Synonyms: Histone-arginine N-methyltransferase PRMT7, KIAA1933, Protein arginine N-methyltransferase 7
Gene ID 54496, 9606
UniProt Q9NVM4
Research Area Chromatin and Nuclear Signaling
Application Notes ELISA: 1/1,000. Western Blot: 1/100-1/500Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-PRMT7 antibody (Protein Arginine Methyltransferase 7) (N-Term) (ABIN356532) anti-Protein Arginine Methyltransferase 7 (PRMT7) (N-Term) antibody
 image for anti-PRMT7 antibody (Protein Arginine Methyltransferase 7) (N-Term) (ABIN356532) anti-Protein Arginine Methyltransferase 7 (PRMT7) (N-Term) antibody (Image 2)
Background publications Lee, Cook, Yang, Mirochnitchenko, Gunderson, Felix, Herth, Hoffmann, Pestka: "PRMT7, a new protein arginine methyltransferase that synthesizes symmetric dimethylarginine." in: The Journal of biological chemistry, Vol. 280, Issue 5, pp. 3656-64, 2005

Miranda, Miranda, Frankel, Clarke: "PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity." in: The Journal of biological chemistry, Vol. 279, Issue 22, pp. 22902-7, 2004

Pal, Yun, Datta, Lacomis, Erdjument-Bromage, Kumar, Tempst, Sif: "mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad." in: Molecular and cellular biology, Vol. 23, Issue 21, pp. 7475-87, 2003

Frankel, Yadav, Lee, Branscombe, Clarke, Bedford: "The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity." in: The Journal of biological chemistry, Vol. 277, Issue 5, pp. 3537-43, 2002

Rho, Choi, Seong, Cho, Kim, Im: "Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family." in: The Journal of biological chemistry, Vol. 276, Issue 14, pp. 11393-401, 2001

Pollack, Kotenko, He, Izotova, Barnoski, Pestka: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, 1999

Gilbreth, Yang, Bartholomeusz, Pimental, Kansra, Gadiraju, Marcus: "Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 25, pp. 14781-6, 1999