DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) (N-Term) antibody

Details for Product No. ABIN356568
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Antigen
Synonyms DNMT3A2, M.HsaIIIA, DNMT3A
Epitope
N-Term
(9), (6), (6), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(80), (30), (23), (13), (1), (1)
Host
Rabbit
(71), (10), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(73), (27), (20), (12), (10), (9), (7), (4), (3), (2)
Pubmed 2 references available
Catalog no. ABIN356568
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human Dnmt3a.
Specificity This antibody is specific to Dnmt3a (N-term). It will cross reacts with Mouse (Predicted by 100% Antigen Homology).
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name DNMT3A
Background CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3a is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
Alternate names: DNA (cytosine-5)-methyltransferase 3A, DNA MTase HsaIIIA, DNA methyltransferase HsaIIIA, M.HsaIIIA
Gene ID 1788
NCBI Accession 9606
UniProt Q9Y6K1
Application Notes ELISA: 1/1,000. Western Blot: 1/50-1/100. Immunohistochemistry: 1/10~1/50. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) (N-Term) antibody anti-DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) (N-Term) antibody
anti-DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) (N-Term) antibody (2) anti-DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) (N-Term) antibody (Image 2)
Background publications Robertson, Uzvolgyi, Liang et al.: "The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors." in: Nucleic acids research, Vol. 27, Issue 11, pp. 2291-8, 1999 (PubMed).

Xie, Wang, Okano et al.: "Cloning, expression and chromosome locations of the human DNMT3 gene family." in: Gene, Vol. 236, Issue 1, pp. 87-95, 1999 (PubMed).

Hosts (71), (10), (2), (2)
Reactivities (80), (30), (23), (13), (1), (1)
Applications (73), (27), (20), (12), (10), (9), (7), (4), (3), (2)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (6), (6), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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