Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (N-Term) antibody

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Antigen
Synonyms H3-K9-HMTase 1, KMT1A, MG44, SUV39H, mIS6, AI852103, AL022883, DXHXS7466e, RGD1565028, fe02c04, suv39h1, wu:fe02c04, zgc:101027, kmt1a, suv39h
Epitope
N-Term
(10), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(37), (22), (16), (14), (14), (12), (1), (1)
Host
Rabbit
(29), (9)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(29), (12), (10), (4), (4), (3), (1)
Pubmed 5 references available
Catalog no. ABIN356686
Quantity 0.4 mL
Price
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Immunogen Purified recombinant GST fusion protein encoding N-terminal of human SUV39H1.
Specificity This antibody is specific to SUV39H1.
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SUV39H1 / KMT1A
Background Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.
Alternate names: Histone H3-K9 methyltransferase 1, Histone-lysine N-methyltransferase SUV39H1, Lysine N- methyltransferase 1A, Position-effect variegation 3-9 homolog, SUV39H, Suppressor of variegation 3-9 homolog 1
Gene ID 6839
NCBI Accession 9606
UniProt O43463
Application Notes ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (N-Term) antibody anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (N-Term) antibody
Background publications Rea, Eisenhaber, OCarroll et al.: "Regulation of chromatin structure by site-specific histone H3 methyltransferases." in: Nature, Vol. 406, Issue 6796, pp. 593-9, 2000 (PubMed).

Vaute, Nicolas, Vandel et al.: "Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases." in: Nucleic acids research, Vol. 30, Issue 2, pp. 475-81, 2002 (PubMed).

Schotta, Ebert, Krauss et al.: "Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing." in: The EMBO journal, Vol. 21, Issue 5, pp. 1121-31, 2002 (PubMed).

Fujita, Watanabe, Ichimura et al.: "Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 24132-8, 2003 (PubMed).

Macaluso, Cinti, Russo et al.: "pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer." in: Oncogene, Vol. 22, Issue 23, pp. 3511-7, 2003 (PubMed).

Hosts (29), (9)
Reactivities (37), (22), (16), (14), (14), (12), (1), (1)
Applications (29), (12), (10), (4), (4), (3), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (2), (1), (1), (1), (1)
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