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SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (C-Term) antibody

Details for Product No. ABIN356734, Supplier: Log in to see
Antigen
  • 4921531N22Rik
  • AI789753
  • anon-EST:Posey240
  • ARABIDOPSIS THALIANA SMALL UBIQUITIN-LIKE MODIFIER 1
  • ATSUMO1
  • AU040360
  • CG4494
  • DAP-1
  • DAP1
  • Dm0342
  • Dmel\\CG4494
  • DmSmt3
  • Dmsmt3
  • DmSUMO-1
  • dsmt3
  • dSmt3
  • F10M23.180
  • F10M23_180
  • Gkap
  • GMP1
  • hm:zeh0670
  • l(2)04493
  • l(2)SH0182
  • l(2)SH2 0182
  • OFC10
  • PIC1
  • pigSUMO1
  • SENP2
  • SENTRIN
  • SMALL UBIQUITIN-LIKE MODIFIER 1
  • small ubiquitin-like modifier 1
  • SMT3
  • Smt3
  • Smt3C
  • SMT3C
  • SMT3H3
  • SMTP3
  • SUM1
  • Sumo
  • SUMO
  • sumo
  • sumo-1
  • SUMO-1
  • SUMO1
  • SUMO 1
  • sumo1
  • UBL1
  • Ubl1
  • wu:fb74c02
  • wu:fd12c02
  • zgc:65934
  • zgc:85634
Epitope
C-Term
49
20
14
14
13
7
6
5
5
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
324
131
86
4
4
3
2
2
1
1
1
Host
Rabbit
205
117
4
2
2
1
1
Clonality
Polyclonal
Conjugate
Un-conjugated
17
15
14
10
7
7
6
6
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
265
120
119
113
107
102
75
57
47
33
9
2
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human SUMO1.
Isotype Ig
Specificity This antibody is specific to SUMO1 (C-term).
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name SUMO1 (SUMO1 Antibody Abstract)
Background Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. The SUMO family consists of SUMO1 and closely related homologs SUMO2, SUMO3, and SUMO4. Sumoylation has been shown to regulate a wide range of proteins, including MDM2, PIAS, PML, RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, PARK2, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, CaMK, DNMT3B, TDG, HIF1A, CHD3, EXOSC9, RAD51, and viral targets such as CMV-IE1/2, EBV-BZLF1, and HPV/BPV-E1.Synonyms: GAP-modifying protein 1, GMP1, SMT3 homolog 3, SMT3C, SMT3H3, Sentrin, Small ubiquitin-related modifier 1, UBL1, Ubiquitin-homology domain protein PIC1, Ubiquitin-like protein SMT3C, Ubiquitin-like protein UBL1
Gene ID 7341, 9606
UniProt P63165
Research Area Signaling, Proteases, DNA/RNA
Application Notes ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Immunofluorescence (see Ref.6).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (C-Term) antibody (ABIN356734) anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (C-Term) antibody
 image for anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (C-Term) antibody (ABIN356734) anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (C-Term) antibody (Image 2)
 image for anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (C-Term) antibody (ABIN356734) anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (C-Term) antibody (Image 3)
Background publications Rathke, Baarends, Jayaramaiah-Raja, Bartkuhn, Renkawitz, Renkawitz-Pohl: "Transition from a nucleosome-based to a protamine-based chromatin configuration during spermiogenesis in Drosophila." in: Journal of cell science, Vol. 120, Issue Pt 9, pp. 1689-700, 2007 (PubMed).

Yang, Sharrocks: "SUMO promotes HDAC-mediated transcriptional repression." in: Molecular cell, Vol. 13, Issue 4, pp. 611-7, 2004 (PubMed).

Ling, Sankpal, Robertson, McNally, Karpova, Robertson: "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription." in: Nucleic acids research, Vol. 32, Issue 2, pp. 598-610, 2004 (PubMed).

Bailey, OHare: "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 692-703, 2003 (PubMed).

Pountney, Huang, Burns, Haan, Thompson, Blumbergs, Gai: "SUMO-1 marks the nuclear inclusions in familial neuronal intranuclear inclusion disease." in: Experimental neurology, Vol. 184, Issue 1, pp. 436-46, 2003 (PubMed).

Ohshima, Shimotohno: "Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 50833-42, 2003 (PubMed).