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Retina and Anterior Neural Fold Homeobox (RAX) (N-Term) antibody

Details for Product No. ABIN356911
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Antigen
Epitope
N-Term
(13), (5), (4), (1), (1), (1), (1), (1)
Reactivity
Human
(30), (5), (5), (3), (1), (1)
Host
Rabbit
(21), (10)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(31), (18), (11), (3), (3)
Pubmed 3 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN356911
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human RAX.
Specificity This antibody detects Rax at N-term.
Purification Protein A column, followed by peptide affinity purification
Alternative Name RAX / RX
Background Rax plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. It binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter.
Alternate names: Retina and anterior neural fold homeobox protein, Retinal homeobox protein Rx
Molecular Weight 36805 Da
Gene ID 30062
NCBI Accession 9606
UniProt Q9Y2V3
Application Notes ELISA 1: 1,000. Western blot 1: 50 - 1: 100. Immunohistochemistry 1: 10 - 1: 50. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Supplier Images
anti-Retina and Anterior Neural Fold Homeobox (RAX) (N-Term) antibody anti-Retina and Anterior Neural Fold Homeobox (RAX) (N-Term) antibody
anti-Retina and Anterior Neural Fold Homeobox (RAX) (N-Term) antibody (2) anti-Retina and Anterior Neural Fold Homeobox (RAX) (N-Term) antibody (Image 2)
Background publications Mathers, Jamrich: "Regulation of eye formation by the Rx and pax6 homeobox genes." in: Cellular and molecular life sciences : CMLS, Vol. 57, Issue 2, pp. 186-94, 2000 (PubMed).

Mikkola, Bruun, Holm et al.: "Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins." in: The Journal of biological chemistry, Vol. 276, Issue 6, pp. 4109-18, 2001 (PubMed).

Voronina, Kozhemyakina, OKernick et al.: "Mutations in the human RAX homeobox gene in a patient with anophthalmia and sclerocornea." in: Human molecular genetics, Vol. 13, Issue 3, pp. 315-22, 2004 (PubMed).

Validation Images
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