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TLR6 antibody (Toll-Like Receptor 6) (C-Term)

Details for Product anti-TLR6 Antibody No. ABIN357055, Supplier: Log in to see
Antigen
  • TLR1
  • TLR16
  • CD286
  • TLR-6
  • toll-like receptor 1-like A
  • toll-like receptor 6
  • TLR1LA
  • TLR6
  • Tlr6
Alternatives
anti-Human TLR6 antibody for Flow Cytometry
Epitope
C-Term
25
22
14
14
11
10
9
9
8
6
5
5
5
5
5
4
3
3
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
208
68
8
3
3
3
Host
Rabbit
134
72
28
Clonality
Polyclonal
Conjugate
This TLR6 antibody is un-conjugated
19
16
14
6
5
5
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
133
95
88
83
50
21
18
11
6
4
2
2
2
1
1
1
Options
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of mouse TLR6.
Isotype Ig
Specificity This antibody detects TLR6 at C-term.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name CD286 / TLR6 (TLR6 Antibody Abstract)
Background TLR6, a Type I membrane protein that belongs to the Toll-like rceptor family, participates in the innate immune response to Gram-positive bacteria and fungi. It acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. It binds to TLR2 via their respective extracellular domains, and to MyD88 via their respective TIR domains. TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.Synonyms: Toll-like receptor 6
Molecular Weight 92407 Da
Gene ID 21899, 10090
UniProt Q9EPW9
Research Area Signaling, Immunology, Inflammation
Pathways TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin
Application Notes ELISA 1: 1,000. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-TLR6 antibody (Toll-Like Receptor 6) (C-Term) (ABIN357055) anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody
 image for anti-TLR6 antibody (Toll-Like Receptor 6) (C-Term) (ABIN357055) anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody (Image 2)
 image for anti-TLR6 antibody (Toll-Like Receptor 6) (C-Term) (ABIN357055) anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody (Image 3)
Background publications Ozinsky, Underhill, Fontenot, Hajjar, Smith, Wilson, Schroeder, Aderem: "The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 25, pp. 13766-71, 2000 (PubMed).

Takeuchi, Kawai, Sanjo, Copeland, Gilbert, Jenkins, Takeda, Akira: "TLR6: A novel member of an expanding toll-like receptor family." in: Gene, Vol. 231, Issue 1-2, pp. 59-65, 1999 (PubMed).