Toll-Like Receptor 6 (TLR6) (C-Term) antibody

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Antigen
Synonyms CD286, TLR-6, TLR1, TLR16
Epitope
C-Term
(17), (8), (5), (5), (5), (5), (5), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(107), (40), (18), (17), (1)
Host
Rabbit
(80), (31), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (6), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(66), (47), (39), (30), (21), (16), (11), (10), (3), (2), (2), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN357055
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of mouse TLR6.
Specificity This antibody detects TLR6 at C-term.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name CD286 / TLR6
Background TLR6, a Type I membrane protein that belongs to the Toll-like rceptor family, participates in the innate immune response to Gram-positive bacteria and fungi. It acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. It binds to TLR2 via their respective extracellular domains, and to MyD88 via their respective TIR domains. TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
Alternate names: Toll-like receptor 6
Molecular Weight 92407 Da
Gene ID 21899
NCBI Accession 10090
UniProt Q9EPW9
Research Area Signaling, Immunology, Inflammation
Application Notes ELISA 1: 1,000. Immunohistochemistry 1: 50 - 1: 100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Supplier Images
anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody
anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody (2) anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody (Image 2)
anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody (3) anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody (Image 3)
Background publications Takeuchi, Kawai, Sanjo et al.: "TLR6: A novel member of an expanding toll-like receptor family." in: Gene, Vol. 231, Issue 1-2, pp. 59-65, 1999 (PubMed).

Ozinsky, Underhill, Fontenot et al.: "The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 25, pp. 13766-71, 2000 (PubMed).

Hosts (80), (31), (8)
Reactivities (107), (40), (18), (17), (1)
Applications (66), (47), (39), (30), (21), (16), (11), (10), (3), (2), (2), (2), (1), (1)
Conjugates (7), (6), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (8), (5), (5), (5), (5), (5), (3), (2), (1), (1), (1), (1), (1)
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