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Toll-Like Receptor 6 (TLR6) (C-Term) antibody

Details for Product No. ABIN357055, Supplier: Login to see
Antigen
  • TLR1
  • TLR16
  • CD286
  • TLR-6
Alternatives
anti-Human Toll-Like Receptor 6 antibody for Flow Cytometry
Epitope
C-Term
36
24
14
14
11
9
9
8
7
5
5
5
3
3
3
2
2
2
2
1
1
Reactivity
Human, Mouse (Murine)
156
52
6
2
2
Host
Rabbit
124
49
7
Clonality
Polyclonal
Conjugate
Un-conjugated
16
15
11
5
5
5
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
114
78
63
52
28
18
15
8
6
4
3
2
2
1
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of mouse TLR6.
Isotype Ig
Specificity This antibody detects TLR6 at C-term.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name CD286 / TLR6 (TLR6 Antibody Abstract)
Background TLR6, a Type I membrane protein that belongs to the Toll-like rceptor family, participates in the innate immune response to Gram-positive bacteria and fungi. It acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. It binds to TLR2 via their respective extracellular domains, and to MyD88 via their respective TIR domains. TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.Synonyms: Toll-like receptor 6
Molecular Weight 92407 Da
Gene ID 21899, 10090
UniProt Q9EPW9
Research Area Signaling, Immunology, Inflammation
Pathways TLR Signaling
Application Notes ELISA 1: 1,000. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody (ABIN357055) anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody
 image for anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody (ABIN357055) anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody (Image 2)
 image for anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody (ABIN357055) anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibody (Image 3)
Background publications Ozinsky, Underhill, Fontenot et al.: "The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 25, pp. 13766-71, 2000 (PubMed).

Takeuchi, Kawai, Sanjo et al.: "TLR6: A novel member of an expanding toll-like receptor family." in: Gene, Vol. 231, Issue 1-2, pp. 59-65, 1999 (PubMed).