Connexin 31 antibody (C-Term)

Catalog No. ABIN357088

Product Details anti-Connexin 31 Antibody

Target: Connexin 31 (GJB3) (Gap Junction Protein, beta 3, 31kDa (GJB3))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Connexin 31 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Connexin 31 (GJB3) at C-term.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human GJB3.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA 1: 1,000. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for Connexin 31

Target: Connexin 31 (GJB3) (Gap Junction Protein, beta 3, 31kDa (GJB3))

Alternative Name: GJB3 / Cx31 (GJB3 Products)

Synonyms: CX31 antibody, DFNA2 antibody, DFNA2B antibody, EKV antibody, Cnx31 antibody, Cx31 antibody, D4Wsu144e antibody, Gjb-3 antibody, ekv antibody, cx31 antibody, dfna2 antibody, gjb3b antibody, dfna2b antibody, connexin-31 antibody, gap junction protein beta 3 antibody, gap junction protein, beta 3 antibody, gap junction protein beta 3 L homeolog antibody, GJB3 antibody, Gjb3 antibody, gjb3.L antibody, gjb3 antibody

Background: Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.Synonyms: Connexin-31, Gap junction beta-3 protein

Molecular Weight: 30818 Da

Gene ID: 2707, 9606

UniProt: O75712

Pathways: Sensory Perception of Sound