Neurogenin 1 antibody (N-Term)

Catalog No. ABIN357407

Product Details anti-Neurogenin 1 Antibody

Target: Neurogenin 1 (NEUROG1)

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurogenin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects NeuroG1 at N-term.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human NeuroG1.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for Neurogenin 1

Target: Neurogenin 1 (NEUROG1)

Alternative Name: Neurogenin 1 (NEUROG1 Products)

Synonyms: ath4c antibody, neurogenin-1 antibody, ngn1 antibody, NEUROG1 antibody, aka antibody, ngn antibody, math4c antibody, neurod3 antibody, neurogenin antibody, neurogenin1 antibody, AKA antibody, Math4C antibody, Neurod3 antibody, bHLHa6 antibody, NEUROD3 antibody, Ngn1 antibody, cb260 antibody, chunp6899 antibody, ngr1 antibody, zNgn1 antibody, neurogenin 1 antibody, NEUROG1 antibody, neurog1 antibody, Neurog1 antibody

Background: Basic helix-loop-helix (bHLH) proteins are transcription factors involved in determining cell type during development. NeuroG1 is a bHLH protein with dual cell-fate specification roles. It functions during neurogenesis, and it has also been shown to inhibit the differentiation of neural stem cells into astrocytes. NeuroG1 promotes neurogenesis by functioning as a transcriptional activator, yet it inhibits astrocyte differentiation by compartmentalizing the CREB-binding protein transcription complex away from astrocyte differentiation genes and by inhibiting STAT transcription factors essential for gliogenesis.Synonyms: NEUROD3, NGN, NGN1, Neurogenic basic-helix-loop-helix protein, Neurogenic differentiation factor 3, Neurogenin 1

Molecular Weight: 25717 Da

Gene ID: 4762

NCBI Accession: NP_006152

UniProt: Q92886