You are viewing an incomplete version of our website. Please click to reload the website as full version.

SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (N-Term)

Details for Product anti-SOX2 Antibody No. ABIN357437, Supplier: Log in to see
Antigen
  • Qscn6
  • Qsox
  • Sox-2
  • rSOx
  • ANOP3
  • MCOPS3
  • RGD1565646
  • SRY-box2
  • Xsox-2
  • anop3
  • mcops3
  • sox-2
  • lcc
  • ysb
  • cb236
  • wu:fb83g04
  • wu:fc14d07
  • zgc:65860
  • zgc:77389
  • SRY (sex determining region Y)-box 2
  • quiescin Q6 sulfhydryl oxidase 1
  • SRY-box containing gene 2
  • LOC100231711
  • Qsox1
  • SOX2
  • Sox2
  • sox2
Alternatives
anti-Human SOX2 antibody for Western Blotting
Epitope
N-Term
55
22
19
18
16
16
15
14
13
11
8
5
5
5
5
4
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Zebrafish (Danio rerio)
441
152
79
30
26
19
16
12
11
10
10
10
7
4
4
4
4
3
3
2
2
1
1
1
1
1
Host
Rabbit
293
156
7
Clonality
Polyclonal
Conjugate
This SOX2 antibody is un-conjugated
21
19
17
16
11
11
8
7
6
6
6
6
4
4
4
4
3
3
3
2
2
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
321
177
134
128
121
98
89
60
14
7
6
6
6
4
2
2
2
1
1
1
1
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Immunogen This SOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97~126 amino selected from the N-terminal region of human SOX2.
Isotype Ig
Specificity This antibody detects SOX2 at N-term.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Zebrafish.
Species reactivity (tested):Human.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name SOX2 (SOX2 Antibody Abstract)
Background The intronless gene for SOX2 encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.Synonyms: ANOP3, MCOPS3, SRY (sex determining region Y)-box 2, SRY-box 2, SRY-related HMG-box gene 2, Transcription factor SOX-2
Molecular Weight 34310 Da (based on amino acid sequence). Theoretical pI: 9.74.
Gene ID 6657, 9606
UniProt P48431
Research Area Embryogenesis, Embryonic stem cells, Reproduction, Transcription Factors, Neural Stem Cell marker
Pathways Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance
Application Notes ELISA: 1/1,000. Western blot: 1/50-1/100. Immunohistochemistry: 1/10-1/50. Immunofluorescence: 1/10-1/50. Flow Cytometry: 1/10-1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (N-Term) (ABIN357437) anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (N-Term) antibody
 image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (N-Term) (ABIN357437) anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (N-Term) antibody (Image 2)
 image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (N-Term) (ABIN357437) anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (N-Term) antibody (Image 3)
 image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (N-Term) (ABIN357437) anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (N-Term) antibody (Image 4)
 image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (N-Term) (ABIN357437) anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (N-Term) antibody (Image 5)
Background publications Reményi, Lins, Nissen, Reinbold, Schöler, Wilmanns: "Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers." in: Genes & development, Vol. 17, Issue 16, pp. 2048-59, 2003 (PubMed).

Wiebe, Nowling, Rizzino: "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 17901-11, 2003 (PubMed).

Fantes, Ragge, Lynch, McGill, Collin, Howard-Peebles, Hayward, Vivian, Williamson, van Heyningen, FitzPatrick: "Mutations in SOX2 cause anophthalmia." in: Nature genetics, Vol. 33, Issue 4, pp. 461-3, 2003 (PubMed).

Schepers, Teasdale, Koopman: "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families." in: Developmental cell, Vol. 3, Issue 2, pp. 167-70, 2002 (PubMed).

Kamachi, Uchikawa, Kondoh: "Pairing SOX off: with partners in the regulation of embryonic development." in: Trends in genetics : TIG, Vol. 16, Issue 4, pp. 182-7, 2000 (PubMed).