Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (C-Term) antibody

Details for Product No. ABIN357465
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Antigen
Synonyms DD5, EDD, EDD1, HYD, 4432411E13Rik, AW549941, C77315, D030042K14, Edd, Edd1, mKIAA0896, Dd5, Rat100
Epitope
C-Term
(15), (7), (4), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(58), (34), (17), (15), (12), (12), (4), (3), (1), (1)
Host
Rabbit
(47), (9), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(37), (29), (25), (17), (10), (5), (3), (2), (2)
Pubmed 3 references available
Quantity 0.4 mL
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Catalog No. ABIN357465
357.50 $
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human EDD.
Isotype Ig
Specificity This antibody detects EDD at C-term.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name UBR5 / HYD
Background EDD is a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22, a locus disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.Synonyms: E3 ubiquitin-protein ligase, E3 ubiquitin-protein ligase UBR5, EDD, EDD1, HECT domain-containing 1, Hyperplastic discs protein homolog, KIAA0896
Molecular Weight 309348 Da
Gene ID 51366, 9606
UniProt O95071
Application Notes ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (C-Term) antibody anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (C-Term) antibody
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (C-Term) antibody (2) anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (C-Term) antibody (Image 2)
Background publications Honda, Tojo, Matsuzaki et al.: "Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response." in: The Journal of biological chemistry, Vol. 277, Issue 5, pp. 3599-605, 2002 (PubMed).

Henderson, Russell, Hird et al.: "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response." in: The Journal of biological chemistry, Vol. 277, Issue 29, pp. 26468-78, 2002 (PubMed).

Clancy, Henderson, Russell et al.: "EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer." in: Oncogene, Vol. 22, Issue 32, pp. 5070-81, 2003 (PubMed).

Validation Images
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