Ubiquitin Specific Peptidase 11 (USP11) (C-Term) antibody

Antigen: Ubiquitin Specific Peptidase 11 (USP11)

Synonyms: UHX1, USP11, MGC6649, KIAA4085, mKIAA4085, 6230415D12Rik, Uhx1, MGC105909, DKFZp459L098

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Catalog no.: ABIN357541

Additional Information

Characteristics: Synonyms: Ubiquitin carboxyl-terminal hydrolase 11, UHX1, Ubiquitin thioesterase 11,Ubiquitin-specific-processing protease 11, Deubiquitinating enzyme 11

Alternative name: USP11

Swiss-Prot: P51784

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated syntheticpeptide selected from the C-terminal region of human USP11.

Cross-Reactivity: Human, Mouse (Murine)

Isotype: Ig  (Matching secondary antibodies)

Description: Modification of target proteins by ubiquitin participates in a wide array of biologicalfunctions. Proteins destined for degradation or processing via the 26 S proteasome arecoupled to multiple copies of ubiquitin. However, attachment of ubiquitin orubiquitin-related molecules may also result in changes in subcellular distribution ormodification of protein activity. An additional level of ubiquitin regulation,deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fallinto four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processingproteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, andJab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPsrepresent the most widespread and represented deubiquitinating enzymes acrossevolution. USPs tend to release ubiquitin from a conjugated protein. They display similarcatalytic domains containing conserved Cys and His boxes but divergent N-terminal andoccasionally C-terminal extensions, which are thought to function in substrate recognition,subcellular localization, and protein-protein interactions.

Specificity: This antibody is specific to USP11 (C-term). Species: Human and Mouse. Others not tested.

Application Details

Application Notes: ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: PBS with 0.09% (W/V) Sodium Azide as preservative.

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. Caution: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Restrictions: For Research Use only