Lethal Giant Larvae Homolog 1 (Drosophila) (LLGL1) (pSer650), (pSer654) antibody

Details for Product No. ABIN357637
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Synonyms LLGL1, DLG4, HUGL, HUGL-1, HUGL1, LLGL, AI325176, Lgl1, Llglh, Mgl1, Rgl1
pSer650, pSer654
(12), (7), (6), (6), (6), (4), (2), (1), (1)
(29), (12), (12)
(25), (4)
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(20), (11), (10), (3), (1), (1)
Pubmed 8 references available
Quantity 0.4 mL
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Catalog No. ABIN357637
357.50 $
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Immunogen KLH conjugated synthetic diphosphopeptide corresponding to amino acid residues surrounding Ser650 and Ser654 of Human LLGL1/2.
Isotype Ig
Purification Protein G Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name LLGL1
Background LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells.Synonyms: DLG4, HGL, HUGL, Hugl-1, Human homolog to the D-lgl gene protein, LLGL, LLGL1, LLGL2, Lethal(2) giant larvae protein homolog 1, Lethal(2) giant larvae protein homolog 2
Molecular Weight 115042 Da and 113448 Da
Gene ID 3996
NCBI Accession NP_004131
UniProt Q15334
Application Notes ELISA: 1/1,000. Western Blot: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
anti-Lethal Giant Larvae Homolog 1 (Drosophila) (LLGL1) (pSer650), (pSer654) antibody anti-Lethal Giant Larvae Homolog 1 (Drosophila) (LLGL1) (pSer650), (pSer654) antibody
Background publications Solinet, Akpovi, Garcia et al.: "Myosin IIB deficiency in embryonic fibroblasts affects regulators and core members of the par polarity complex." in: Histochemistry and cell biology, Vol. 136, Issue 3, pp. 245-66, 2011 (PubMed).

Sutton, Gay, Edmunds et al.: "Modelling the force of infection for hepatitis B and hepatitis C in injecting drug users in England and Wales." in: BMC infectious diseases, Vol. 6, pp. 93, 2006 (PubMed).

Schimanski, Schmitz, Kashyap et al.: "Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer." in: Oncogene, Vol. 24, Issue 19, pp. 3100-9, 2005 (PubMed).

Yasumi, Sakisaka, Hoshino et al.: "Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division." in: The Journal of biological chemistry, Vol. 280, Issue 8, pp. 6761-5, 2005 (PubMed).

Grifoni, Garoia, Schimanski et al.: "The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo." in: Oncogene, Vol. 23, Issue 53, pp. 8688-94, 2004 (PubMed).

Katoh, Katoh: "Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico." in: International journal of oncology, Vol. 24, Issue 3, pp. 737-42, 2004 (PubMed).

Bi, Yan, Stankiewicz et al.: "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse." in: Genome research, Vol. 12, Issue 5, pp. 713-28, 2002 (PubMed).

Ludford-Menting, Thomas, Crimeen et al.: "A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization." in: The Journal of biological chemistry, Vol. 277, Issue 6, pp. 4477-84, 2002 (PubMed).

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