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CBX8 antibody (Chromobox Homolog 8) (C-Term)

Details for Product anti-CBX8 Antibody No. ABIN357753, Supplier: Log in to see
Antigen
  • cbx8
  • MGC147589
  • Pc3
  • PC3
  • RC1
  • chromobox homolog 8
  • chromobox 8
  • chromobox homolog 8a (Pc class homolog, Drosophila)
  • cbx8
  • CBX8
  • Cbx8
  • cbx8a
Epitope
C-Term
22
20
18
15
8
8
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
122
52
21
8
6
5
4
3
3
3
2
2
2
2
1
Host
Rabbit
66
49
16
Clonality
Polyclonal
Conjugate
This CBX8 antibody is un-conjugated
5
5
5
5
5
5
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
113
59
37
13
13
9
3
2
2
1
1
1
Options
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CBX8.
Isotype Ig
Specificity This antibody is specific to CBX8 (C-term).
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CBX8 (CBX8 Antibody Abstract)
Background Chromobox homolog 8 (CBX8 or Pc3) is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators and thus are essential for proper development. Changes in expression of PcG proteins have been associated with cancer. CBX8 is involved in maintaining the transcriptionally repressive state of genes. It modifies chromatin, rendering it heritably changed in its expressibility. Structurally, CBX4 contains 1 chromo domain, which is 40 to 50 amino acids long.Synonyms: Chromobox protein homolog 8, PC3, Polycomb 3 homolog, RC1, Rectachrome 1
Molecular Weight 43437 Da
Gene ID 57332, 9606
UniProt Q9HC52
Application Notes ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-CBX8 antibody (Chromobox Homolog 8) (C-Term) (ABIN357753) anti-Chromobox Homolog 8 (CBX8) (C-Term) antibody
 image for anti-CBX8 antibody (Chromobox Homolog 8) (C-Term) (ABIN357753) anti-Chromobox Homolog 8 (CBX8) (C-Term) antibody (Image 2)
Background publications Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Bárdos, Saurin, Tissot, Duprez, Freemont: "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties." in: The Journal of biological chemistry, Vol. 275, Issue 37, pp. 28785-92, 2000 (PubMed).