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Peptidyl Arginine Deiminase, Type IV (PADI4) (C-Term) antibody

Details for Product No. ABIN357799, Supplier: Log in to see
Antigen
  • PAD
  • PAD4
  • PADI5
  • PDI4
  • PDI5
  • Pad4
  • Pdi4
Epitope
C-Term
15
13
4
4
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
92
9
7
1
1
1
1
1
1
1
Host
Rabbit
55
21
15
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
70
28
21
19
12
11
6
5
4
4
2
2
1
1
1
1
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PAD4.
Isotype Ig
Specificity This antibody detects PAD4 (C-term).
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name PADI4 (PADI4 Antibody Abstract)
Background PAD4 is a member of a family of enzymes responsible for the conversion of arginine residues to citrulline residues via catalyzation of the deimination of the arginine residues. PAD4 down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. This protein may play a role in granulocyte and macrophage development leading to inflammation and immune response.Synonyms: HL-60 PAD, PAD4, PADI-H, PADI5, PDI4, PDI5, Peptidylarginine deiminase IV, Protein-arginine deiminase type IV, Protein-arginine deiminase type-4
Molecular Weight 74095 Da
Gene ID 23569, 9606
UniProt Q9UM07
Pathways
Application Notes ELISA: 1/1,000. Western Blot: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-Peptidyl Arginine Deiminase, Type IV (PADI4) (C-Term) antibody (ABIN357799) anti-Peptidyl Arginine Deiminase, Type IV (PADI4) (C-Term) antibody
Background publications Nakayama-Hamada, Suzuki, Kubota et al.: "Comparison of enzymatic properties between hPADI2 and hPADI4." in: Biochemical and biophysical research communications, Vol. 327, Issue 1, pp. 192-200, 2005 (PubMed).

Wang, Wysocka, Sayegh et al.: "Human PAD4 regulates histone arginine methylation levels via demethylimination." in: Science (New York, N.Y.), Vol. 306, Issue 5694, pp. 279-83, 2004 (PubMed).