Peptidyl Arginine Deiminase, Type IV (PADI4) (C-Term) antibody

Details for Product No. ABIN357799
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Antigen
Synonyms PAD, PAD4, PADI5, PDI4, PDI5, Pad4, Pdi4
Epitope
C-Term
(13), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(59), (7), (7), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(44), (10), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(49), (20), (16), (11), (10), (9), (8), (5), (3), (1), (1), (1)
Pubmed 2 references available
Quantity 0.4 mL
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Catalog No. ABIN357799
357.50 $
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PAD4.
Specificity This antibody detects PAD4 (C-term).
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name PADI4
Background PAD4 is a member of a family of enzymes responsible for the conversion of arginine residues to citrulline residues via catalyzation of the deimination of the arginine residues. PAD4 down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. This protein may play a role in granulocyte and macrophage development leading to inflammation and immune response.
Alternate names: HL-60 PAD, PAD4, PADI-H, PADI5, PDI4, PDI5, Peptidylarginine deiminase IV, Protein- arginine deiminase type IV, Protein-arginine deiminase type-4
Molecular Weight 74095 Da
Gene ID 23569, 9606
UniProt Q9UM07
Application Notes ELISA: 1/1,000. Western Blot: 1/100-1/500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Peptidyl Arginine Deiminase, Type IV (PADI4) (C-Term) antibody anti-Peptidyl Arginine Deiminase, Type IV (PADI4) (C-Term) antibody
Background publications Wang, Wysocka, Sayegh et al.: "Human PAD4 regulates histone arginine methylation levels via demethylimination." in: Science (New York, N.Y.), Vol. 306, Issue 5694, pp. 279-83, 2004 (PubMed).

Nakayama-Hamada, Suzuki, Kubota et al.: "Comparison of enzymatic properties between hPADI2 and hPADI4." in: Biochemical and biophysical research communications, Vol. 327, Issue 1, pp. 192-200, 2005 (PubMed).

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