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SMC2 antibody (MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]..") (C-Term)

Details for Product anti-SMC2 Antibody No. ABIN357820, Supplier: Log in to see
Antigen
  • CAP-E
  • CAPE
  • SMC-2
  • SMC2L1
  • 5730502P04Rik
  • AI255214
  • AW545314
  • Fin16
  • Smc2l1
  • fb92e05
  • wu:fb92e05
  • zeh1628
  • zgc:55326
  • xcap-e
  • SCII
Epitope
C-Term
12
7
3
2
1
1
1
1
1
1
Reactivity
Human
44
8
7
2
2
2
2
Host
Rabbit
35
5
4
2
Clonality
Polyclonal
Conjugate
This SMC2 antibody is un-conjugated
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
44
11
6
2
2
2
2
2
1
1
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human SMC2.
Isotype Ig
Specificity This antibody detects SMC2 (C-term).
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SMC2 / CAPE (SMC2 Antibody Abstract)
Background SMC2 is a central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.Synonyms: CAP-E, Chromosome-associated protein E, SMC protein 2, SMC-2, SMC2L1, Structural maintenance of chromosomes protein 2, XCAP-E homolog
Molecular Weight 135656 Da
Gene ID 10592
NCBI Accession NP_001036015
UniProt O95347
Application Notes ELISA: 1/1,000. Western Blot: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-SMC2 antibody (MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010].. anti-Structural Maintenance of Chromosomes 2 (SMC2) (C-Term) antibody
Background publications Ham, Takakuwa, Rahadiani et al.: "Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma." in: Cancer science, Vol. 98, Issue 7, pp. 1041-7, 2007 (PubMed).

Schmiesing, Ball, Gregson et al.: "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 22, pp. 12906-11, 1998 (PubMed).