AKR1B1 antibody (Center)

Catalog No. ABIN357881

Product Details anti-AKR1B1 Antibody

Target: AKR1B1 (Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1))

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKR1B1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects AKR1B1/ALDR1 (Center).

Purification: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human AKR1B1.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Western Blot: 1/50-1/100Immunohistochemistry: 1/10-1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for AKR1B1

Target: AKR1B1 (Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1))

Alternative Name: AKR1B1 / ALDR1 (AKR1B1 Products)

Synonyms: ADR antibody, ALDR1 antibody, ALR2 antibody, AR antibody, ALDRED antibody, ALR-P-I antibody, Akr1b3 antibody, Akr1b4 antibody, Aldr1 antibody, Alr antibody, RATALDRED antibody, akr1b7 antibody, zgc:86611 antibody, aldo-keto reductase family 1 member B antibody, aldo-keto reductase family 1, member B1 (aldose reductase) antibody, aldo-keto reductase family 1, member B1 (aldose reductase) S homeolog antibody, AKR1B1 antibody, Akr1b1 antibody, akr1b1.S antibody, akr1b1 antibody

Background: AKR1B1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol.Synonyms: Aldose reductase

Molecular Weight: 35853 Da

Gene ID: 231, 9606

UniProt: P15121

Pathways: Metabolism of Steroid Hormones and Vitamin D, C21-Steroid Hormone Metabolic Process, Monocarboxylic Acid Catabolic Process