SNURF antibody (Middle Region)

Catalog No. ABIN357983

Product Details anti-SNURF Antibody

Target: SNURF (SNRPN Upstream Reading Frame (SNURF))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNURF antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects SNURF (Center).

Purification: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human SNURF.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Western Blot: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for SNURF

Target: SNURF (SNRPN Upstream Reading Frame (SNURF))

Alternative Name: SNURF (SNURF Products)

Synonyms: 2410045I01Rik antibody, Snrpn antibody, SNRPN upstream reading frame antibody, small nuclear ribonucleoprotein polypeptide N antibody, SNURF antibody, SNRPN antibody, Snurf antibody

Background: SNURF is a highly basic protein localized to the nucleus. The evolutionarily constrained open reading frame of its gene is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N. The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center. Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region but the full-length nature of these transcripts has not been determined. An alternate exon has been identified that substitutes for exon 4 and leads to a truncated, monocistronic transcript. Alternative splicing or deletion caused by a translocation event in the 5' UTR or coding region of this gene leads to Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. The function of this protein is not yet known.Synonyms: SNRPN upstream reading frame protein

Molecular Weight: 8412 Da (Theoretical pI: 10.58. WB band detected at approx 30kDa).

Gene ID: 8926, 9606

UniProt: Q9Y675