tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide (YWHAE) (pSer58) antibody

Antigen: tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide (YWHAE)

Synonyms: MDS, MDCR, KCIP-1, 14-3-3E, FLJ45465, AU019196, 14-3-3e, 14-3-3, 14-3-3-e, CT24092, D14-3-3e, D14-3-3epsilon, EK3-5, PAR5, Par-5, SR3-9, Su(Raf)3B, anon-WO0172774.141, anon-WO02059370.52, l(3)j2B10, DmelCG31196, CG31196, LOC443300, YWHAE, mds, mdcr, kcip-1, MGC89915, 14-3-3epsilon, LOC581376, Ywhae, ACYPI002517, ywhae, zgc:55377, zgc:77062, wu:fb48f06, wu:fi22e10, MGC53170

Epitope: pSer58

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Catalog no.: ABIN358060

Additional Information

Characteristics: Synonyms: 14-3-3E, YWHAE

Alternative name: 14-3-3 protein epsilon

Gene ID: 7531

Swiss-Prot: P62258

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated syntheticphosphopeptide corresponding to amino acid residues surrounding S58 of human 14-3-3.

Cross-Reactivity: Human

Isotype: Ig  (Matching secondary antibodies)

Description: The 14-3-3 family of proteins mediate signal transduction by binding tophosphoserine-containing proteins. This highly conserved protein family is found in bothplants and mammals, and this protein is 100% identical to the mouse ortholog. It interactswith CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diversebiochemical activities related to signal transduction, such as cell division and regulation ofinsulin sensitivity. It has also been implicated in the pathogenesis of small cell lungcancer.

Specificity: This antibody detects 14-3-3E pSer58. Predicted to cross react with Mouse (100% Antigen Homology). Species: Human. Others not tested. Add. Information: Molecular weight: 29174 Da

Synonyms: MDS, MDCR, KCIP-1, 14-3-3E, FLJ45465, AU019196, 14-3-3e, 14-3-3, 14-3-3-e, CT24092, D14-3-3e, D14-3-3epsilon, EK3-5, PAR5, Par-5, SR3-9, Su(Raf)3B, anon-WO0172774.141, anon-WO02059370.52, l(3)j2B10, DmelCG31196, CG31196, LOC443300, YWHAE, mds, mdcr, kcip-1, MGC89915, 14-3-3epsilon, LOC581376, Ywhae, ACYPI002517, ywhae, zgc:55377, zgc:77062, wu:fb48f06, wu:fi22e10, MGC53170

Application Details

Application Notes: ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: PBS with 0.09% (W/V) Sodium Azide as preservative.

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. Caution: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Restrictions: For Research Use only