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MAP3K7 antibody (pSer192)

MAP3K7 Reactivity: Human DB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN358312
  • Target See all MAP3K7 Antibodies
    MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))
    Binding Specificity
    • 18
    • 10
    • 9
    • 8
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer192
    Reactivity
    • 108
    • 40
    • 28
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 102
    • 6
    • 1
    Rabbit
    Clonality
    • 99
    • 10
    Polyclonal
    Conjugate
    • 68
    • 8
    • 8
    • 7
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAP3K7 antibody is un-conjugated
    Application
    • 86
    • 65
    • 46
    • 15
    • 10
    • 8
    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Dot Blot (DB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects TAK1 / MAP3K7 pSer192.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse (100 % Antigen Homology).
    Species reactivity (tested):Human.
    Purification
    Protein A Chromatography followed by two-step phosphospecific peptide affinity purification
    Immunogen
    KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Ser192 of Human MAP3K7. Genename: MAP3K7
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MAP3K7 Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Dot Blot: 1/100-1/500.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS, 0.09 % (W/V) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))
    Alternative Name
    TAK1 / MAP3K7 (MAP3K7 Products)
    Synonyms
    si:ch211-225h9.1 antibody, zgc:110612 antibody, Tak1 antibody, MEKK7 antibody, TAK1 antibody, TGF1a antibody, B430101B05 antibody, C87327 antibody, mitogen-activated protein kinase kinase kinase 7 antibody, mitogen activated protein kinase kinase kinase 7 antibody, map3k7 antibody, Map3k7 antibody, MAP3K7 antibody
    Background
    MAP3K7 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2, this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses.Synonyms: Mitogen-activated protein kinase kinase kinase 7, TAK-1, TAK1, TGF-beta-activated kinase 1, Transforming growth factor-beta-activated kinase 1
    Molecular Weight
    67196 Da
    Gene ID
    6885, 9606
    UniProt
    O43318
    Pathways
    NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway
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