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GFAP antibody (Glial Fibrillary Acidic Protein) (pSer8)

Details for Product anti-GFAP Antibody No. ABIN358488, Supplier: Log in to see
Antigen
  • GFAP
  • AI836096
  • cb345
  • etID36982.3
  • gfapl
  • wu:fb34h11
  • wu:fk42c12
  • xx:af506734
  • zgc:110485
Epitope
pSer8
70
69
29
27
23
13
13
6
6
6
5
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
561
215
205
91
89
39
26
24
19
16
11
10
6
5
4
4
3
3
2
2
1
1
1
1
1
1
1
1
Host
Rabbit
336
294
27
24
4
3
2
Clonality
Polyclonal
Conjugate
This GFAP antibody is un-conjugated
29
23
19
11
11
11
7
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
2
2
1
1
1
1
Application
Enzyme Immunoassay (EIA)
484
282
168
166
164
151
70
49
33
21
14
12
11
9
8
7
7
6
5
3
1
1
1
1
1
1
1
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the ?-terminal region of human Phospho-GFAP-Ser8.
Isotype Ig
Specificity This antibody detects GFAP pSer8.
Purification Protein A Chromatography followed by two-step phosphospecific peptide affinity purification.
Alternative Name GFAP (GFAP Antibody Abstract)
Background GFAP is one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system.Synonyms: Glial Fibrillary Acidic Protein
Molecular Weight 49880 Da
Gene ID 2670
NCBI Accession NP_001124491
UniProt P14136
Research Area Stem Cells, Cytoskeleton, Glia marker, Cell/Tissue Markers, Neurology
Pathways
Application Notes ELISA: 1/1,000. Dot Blot: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-GFAP antibody (Glial Fibrillary Acidic Protein) (pSer8) (ABIN358488) anti-Glial Fibrillary Acidic Protein (GFAP) (pSer8) antibody
Background publications Quintanar, Franco, Salinas: "Detection of glial fibrillary acidic protein and neurofilaments in the cerebrospinal fluid of patients with neurocysticercosis." in: Parasitology research, Vol. 90, Issue 4, pp. 261-3, 2003 (PubMed).

Shiroma, Kanazawa, Kato et al.: "Molecular genetic study in Japanese patients with Alexander disease: a novel mutation, R79L." in: Brain & development, Vol. 25, Issue 2, pp. 116-21, 2003 (PubMed).

Namekawa, Takiyama, Aoki et al.: "Identification of GFAP gene mutation in hereditary adult-onset Alexander's disease." in: Annals of neurology, Vol. 52, Issue 6, pp. 779-85, 2002 (PubMed).

Lopez-Egido, Cunningham, Berg et al.: "Menin's interaction with glial fibrillary acidic protein and vimentin suggests a role for the intermediate filament network in regulating menin activity." in: Experimental cell research, Vol. 278, Issue 2, pp. 175-83, 2002 (PubMed).

Nielsen, Holm, Johansen et al.: "A new splice variant of glial fibrillary acidic protein, GFAP epsilon, interacts with the presenilin proteins." in: The Journal of biological chemistry, Vol. 277, Issue 33, pp. 29983-91, 2002 (PubMed).