ANTXR1 antibody (pTyr425)

Catalog No. ABIN358529

Product Details anti-ANTXR1 Antibody

Target: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Binding Specificity: pTyr425

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANTXR1 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Specificity: This antibody detects Anthrax Toxin Receptor 1 (ANTXR1) pTyr425.

Purification: Protein A Chromatography followed by two-step phosphospecific peptide affinity purification.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y425 of human ANTXR1.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Dot Blot: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for ANTXR1

Target: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Alternative Name: Anthrax Toxin Receptor 1 (ANTXR1 Products)

Synonyms: ANTXR1 antibody, ATR antibody, TEM8 antibody, 2310008J16Rik antibody, 2810405N18Rik antibody, Antrx1 antibody, Tem8 antibody, anthrax toxin receptor 1 antibody, ANTXR1 antibody, Antxr1 antibody

Background: ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.Synonyms: ANTXR1, ATR, TEM8, Tumor endothelial marker 8

Molecular Weight: 62789 Da

Gene ID: 84168, 9606

UniProt: Q9H6X2