Heart and Neural Crest Derivatives Expressed 2 (HAND2) (C-Term) antibody

Details for Product No. ABIN358596, Supplier: Log in to see
Antigen
  • DHAND2
  • Hed
  • Thing2
  • bHLHa26
  • dHand
  • dhand2
  • hand2
  • xhand2
  • hand2-b
  • Hand2'
  • dHAND
  • HAND2
  • hed
  • dhand
  • thing2
  • LOC100218345
  • AI225906
  • AI661148
  • Ehand2
  • Th2
  • zdHAND
  • zgc:103415
  • Hand2
  • heart and neural crest derivatives expressed 2
  • heart and neural crest derivatives expressed transcript 2
  • dHAND basic helix-loop-helix transcription factor
  • HAND2
  • Hand2
  • hand2-a
  • hand2-b
  • hand2
  • LOC100218345
  • DHAND
Alternatives
anti-Human Heart and Neural Crest Derivatives Expressed 2 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
C-Term
32
12
10
10
10
8
7
6
3
2
1
Reactivity
Human
80
10
10
8
5
3
3
3
3
2
2
2
2
1
Host
Rabbit
55
22
15
Clonality
Polyclonal
Conjugate
Un-conjugated
6
6
5
5
5
5
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
67
64
26
9
8
4
3
2
1
1
1
Options
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human HAND2.
Isotype Ig
Specificity This antibody reacts to HAND2.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name HAND2 / DHAND (HAND2 Antibody Abstract)
Background HAND2 belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.Synonyms: BHLHA26, Class A basic helix-loop-helix protein 26, Deciduum heart autonomic nervous system and neural crest derivatives-expressed protein 2, Heart- and neural crest derivatives-expressed protein 2
Gene ID 9464
NCBI Accession NP_068808
UniProt P61296
Pathways Tube Formation, Feeding Behaviour
Application Notes ELISA: 1/1,000. Western Blot: 1/50 - 1/200. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-Heart and Neural Crest Derivatives Expressed 2 (HAND2) (C-Term) antibody (ABIN358596) anti-Heart and Neural Crest Derivatives Expressed 2 (HAND2) (C-Term) antibody
 image for anti-Heart and Neural Crest Derivatives Expressed 2 (HAND2) (C-Term) antibody (ABIN358596) anti-Heart and Neural Crest Derivatives Expressed 2 (HAND2) (C-Term) antibody (Image 2)
Background publications Zaffran, Xu, Lo, Lee, Frasch: "Cardiogenesis in the Drosophila model: control mechanisms during early induction and diversification of cardiac progenitors." in: Cold Spring Harbor symposia on quantitative biology, Vol. 67, pp. 1-12, 2003 (PubMed).

McFadden, Charité, Richardson, Srivastava, Firulli, Olson: "A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart." in: Development (Cambridge, England), Vol. 127, Issue 24, pp. 5331-41, 2001 (PubMed).

Russell, Kemp, Wang, Brody, Izumo: "Molecular cloning of the human HAND2 gene." in: Biochimica et biophysica acta, Vol. 1443, Issue 3, pp. 393-9, 1999 (PubMed).

Srivastava: "HAND proteins: molecular mediators of cardiac development and congenital heart disease." in: Trends in cardiovascular medicine, Vol. 9, Issue 1-2, pp. 11-8, 1999 (PubMed).

Firulli, McFadden, Lin, Srivastava, Olson: "Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1." in: Nature genetics, Vol. 18, Issue 3, pp. 266-70, 1998 (PubMed).

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