Baculoviral IAP Repeat-Containing 7 (BIRC7) (C-Term) antibody

Details for Product No. ABIN358607, Supplier: Log in to see
Antigen
  • TIAP2
  • zgc:165605
  • EIAP/XLX
  • XLX
  • kiap
  • livin
  • ml-iap
  • mliap
  • rnf50
  • xEIAP
  • KIAP
  • LIVIN
  • ML-IAP
  • MLIAP
  • RNF50
  • RGD1562883
  • E130019N06
  • Livin
  • baculoviral IAP repeat-containing 5-like
  • baculoviral IAP repeat containing 7
  • baculoviral IAP repeat-containing 7
  • baculoviral IAP repeat-containing 7 (livin)
  • Birc5l
  • BIRC7
  • birc7
  • Birc7
Epitope
C-Term
41
15
11
8
5
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
167
28
26
5
3
3
1
Host
Rabbit
106
41
21
Clonality
Polyclonal
Conjugate
Un-conjugated
6
6
5
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
134
52
45
33
29
28
13
9
7
2
2
1
1
1
1
1
1
1
Options
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human BIRC7.
Isotype Ig
Specificity This antibody reacts to BIRC7.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name BIRC7 / LIVIN (BIRC7 Antibody Abstract)
Background BIRC7 is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.Synonyms: Baculoviral IAP repeat-containing protein 7, KIAP, Kidney inhibitor of apoptosis protein, Livin, MLIAP, Melanoma inhibitor of apoptosis protein, RING finger protein 50, RNF50
Gene ID 79444, 5874
UniProt Q96CA5
Application Notes ELISA: 1/1,000. Western Blot: 1/50 - 1/200. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-Baculoviral IAP Repeat-Containing 7 (BIRC7) (C-Term) antibody (ABIN358607) anti-Baculoviral IAP Repeat-Containing 7 (BIRC7) (C-Term) antibody
 image for anti-Baculoviral IAP Repeat-Containing 7 (BIRC7) (C-Term) antibody (ABIN358607) anti-Baculoviral IAP Repeat-Containing 7 (BIRC7) (C-Term) antibody (Image 2)
Background publications Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Gazzaniga, Gradilone, Giuliani, Gandini, Silvestri, Nofroni, Saccani, Frati, Aglianò: "Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer." in: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, Vol. 14, Issue 1, pp. 85-90, 2002 (PubMed).

Vucic, Deshayes, Ackerly, Pisabarro, Kadkhodayan, Fairbrother, Dixit: "SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)." in: The Journal of biological chemistry, Vol. 277, Issue 14, pp. 12275-9, 2002 (PubMed).

Sanna, da Silva Correia, Ducrey, Lee, Nomoto, Schrantz, Deveraux, Ulevitch: "IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition." in: Molecular and cellular biology, Vol. 22, Issue 6, pp. 1754-66, 2002 (PubMed).

Kasof, Gomes: "Livin, a novel inhibitor of apoptosis protein family member." in: The Journal of biological chemistry, Vol. 276, Issue 5, pp. 3238-46, 2001 (PubMed).