MLL3 (C-Term) antibody

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Antigen
Epitope
C-Term
(14), (13), (1), (1)
Reactivity
Human
(16)
Host
Rabbit
(16)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(14), (11), (3), (1)
Pubmed 5 references available
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Quantity 0.4 mL
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MLL3.
Isotype Ig
Specificity This antibody reacts to MLL3.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Background The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL family, including MLL3. The MLL SET domain is a histone H3 Lys4 (K4)-specific methyltransferase whose activity is stimulated with acetylated H3 peptides. MLL3 maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia. The deduced MLL3 4,911-amino acid protein is more closely related to MLL2 than to MLL1 or MLL4. MLL3 has 6 plant homeodomain (PHD) fingers preceded by a cys-rich ZNF1 domain in its N terminus, a high mobility group (HMG) box, an ATPase alpha-beta signature, and a leucine zipper motif in its central region, and 2 C-terminal FY (phe-tyr) motifs and the SET domain preceded by a ZNF2 domain in its C terminus. The predicted protein also contains several putative nuclear localization motifs. Isoform II lacks ZNF1 and the PHD.Synonyms: HALR, Histone-lysine N-methyltransferase MLL3, Homologous to ALR protein, KIAA1506, KMT2C, Lysine N-methyltransferase 2C, Myeloid/lymphoid or mixed-lineage leukemia protein 3
Gene ID 58508, 9606
UniProt Q8NEZ4
Application Notes ELISA: 1/1,000. Western blotting: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
Image no. 1 for anti-MLL3 (C-Term) antibody (ABIN358665) anti-MLL3 (C-Term) antibody
Background publications Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Hillier, Fulton, Fulton et al.: "The DNA sequence of human chromosome 7. ..." in: Nature, Vol. 424, Issue 6945, pp. 157-64, 2003 (PubMed).

Goo, Sohn, Kim et al.: "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins." in: Molecular and cellular biology, Vol. 23, Issue 1, pp. 140-9, 2002 (PubMed).

Tan, Chow: "Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects." in: Cancer detection and prevention, Vol. 25, Issue 5, pp. 454-69, 2001 (PubMed).

Nagase, Kikuno, Ishikawa et al.: "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 2, pp. 143-50, 2000 (PubMed).

Catalog No. ABIN358665
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